Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q69ZJ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q69ZJ7-F1 | Predicted | AlphaFoldDB |
No variants for Q69ZJ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q69ZJ7 | |||||
No associated diseases with Q69ZJ7
1 regional properties for Q69ZJ7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Ribosomal protein L21e, conserved site | 37 - 62 | IPR018259 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| Ric1-Rgp1 guanyl-nucleotide exchange factor complex | A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cranial skeletal system development | The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| negative regulation of protein catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| regulation of extracellular matrix constituent secretion | Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYFLSGWPKR | LLCAPRSPAE | APLHVQSDPR | RAFFAVLAPA | RLSIWYSRPS | VLIVTYKEPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSSTQFGSYK | QAEWRPDSTM | IAVSTANGYI | LFFHITSSRG | DKYLYEPVYP | KGSPQMKGIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HFKEEHCAPA | LNLEMKKILD | LQAPIMSLQS | VLEDLLVATS | DGLLHLIHWE | GMTNGRKAIN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSTVPFSVDL | QSSRVGSFLG | FADVHIKDME | YCATLDGFAV | VFNDGKVGFI | TPVSSRFTAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLHGVWPQDV | IDGTCVAVNN | KYRLMAFGCA | SGCVQVYTID | NTTGAMLLSH | KLELTAKQYP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DIWNKTGAVK | LIRWSPDNSA | VIVTWEYGGL | SLWSVFGAQL | ICTLGGDFAY | RSDGTKKDPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KINSMSWGAE | GYHLWVISGL | GSQHTQIETD | LRSTVKEPSI | LLFQFIKSVL | TVNPCMSNQE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QVLLQGEDRL | YLNCGEASQA | QNPKYSSARA | ERMPRHEKSP | FADGGLEAPG | LSTLLGHRHW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HVVQISSTYL | ESNWPIRFSA | IDKLGQNIAV | AGKFGFAHYS | LLTKKWKLFG | NITQEQNMIV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TGGLAWWDDF | MVLACYNLSD | CQEELRIYLR | TSNLDNAFAH | VTKAPMETLL | LSVFRDMVVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FRADCSICLY | SIERKSDGSN | TTASVQVLQE | VSMSRYIPHP | FLVVSVTLTS | VSTENGISLK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MPQQARDAES | IMLNLAGQLI | MMQRDRSGPQ | IREKDSHPNQ | RKLLPFCPPV | VLAQSVENVW |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TTCRANKQKR | HLLEALWLSC | GGAGMKVWLP | LFPRDHRKPH | SFLSQRIMLP | FHINIYPLAV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LFEDALVLGA | VNDTLLYDSL | YTRSSAREQL | EVLFPFCVVE | RTSQIYLHHI | LRQLLVRNLG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EQALLLAQSC | AALPYFPHVL | ELMLHEVLEE | EATSREPIPD | PLLPTVAKFI | TEFPLFLQTV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VHCARKTEYA | LWNYLFAAVG | NPKDLFEECL | MAQDLDTAAS | YLIILQNMEV | PAVSRQHATL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LFNTALEQGK | WDLCRHMIRF | LKAIGSGESE | TPPSTPTSQE | PSSSGGFEFF | RNRSISLSQS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AENVPPGKFG | LQKTLSMPTG | PSGKRWSKDS | ECAENMYIDM | MLWRHARRLL | EEVRLKDLGC |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FAAQLGFELI | SWLCKERTRA | ARVDNFVVAL | KRLHKDFLWP | LPIIPASSIS | SPFKNGKCRA |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VGEQMLKSQS | ADPFITPEMD | AGISNIQRSQ | SWLSNIGPTH | RDTDRASSPG | PQMQDAFLSP |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LSNKGDECSI | GSATDLTESS | SVVDGDWTMV | DENFSTLSLT | QSELEHISME | LASKGPHKSQ |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VQLRYLLHIF | MEAGCLDWCV | VIGLILRESS | VVSQLLGIAQ | SSEMDGEMLQ | NIKSGLQAVD |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| RWASTDCPGY | KPFLNIIKPQ | LQKLSEITEE | LVQPDTFQPV | TVGKTPEQTS | PRAEENRGSC |
| 1390 | 1400 | 1410 | 1420 | ||
| SHGSISQSEP | GSNNVVSRKE | EDTTQADEEE | PLQDGAYDCS | VS |