P40395

PR
Gene name
RIC1
Protein name
Guanine nucleotide exchange factor subunit RIC1
Names
Protein RIC1, Ribosome control protein 1, Ric1p
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR039C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

405-482 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40395

Entry ID Method Resolution Chain Position Source
AF-P40395-F1 Predicted AlphaFoldDB

19 variants for P40395

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-228570 10 T>S No SGRP
s12-228375 75 P>A No SGRP
s12-228285 105 T>A No SGRP
s12-228197 134 K>R No SGRP
s12-227807 264 M>T No SGRP
s12-227508 364 N>Y No SGRP
s12-227354 415 N>S No SGRP
s12-227042 519 I>T No SGRP
s12-227016 528 K>E No SGRP
s12-226833 589 L>M No SGRP
s12-226729 623 M>I No SGRP
s12-226578 674 V>L No SGRP
s12-226565 678 Q>R No SGRP
s12-226439 720 I>T No SGRP
s12-226307 764 E>G No SGRP
s12-225932 889 T>I No SGRP
s12-225756 948 V>I No SGRP
s12-225677 974 T>S No SGRP
s12-225621 993 T>A No SGRP

No associated diseases with P40395

1 regional properties for P40395

Type Name Position InterPro Accession
domain Ribosome control protein 1 786 - 1044 IPR009771

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
guanyl-nucleotide exchange factor complex A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
Ric1-Rgp1 guanyl-nucleotide exchange factor complex A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi.

1 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

3 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4ADV7 RIC1 Guanine nucleotide exchange factor subunit RIC1 Homo sapiens (Human) PR
Q69ZJ7 Ric1 Guanine nucleotide exchange factor subunit RIC1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MFIKQSEKNT PKCLYKKKGK VRVLLTGSCK KLNTWKMHLW PVSPPQLLRI PPRNAELGEG
70 80 90 100 110 120
TKIDDCNILQ SMTLPQANVL IMLTPTRVLI YNFKPMALVA SHERTMASLK EFGDNRSMKR
130 140 150 160 170 180
SAPYNDIIEG LISKKDSQYL LWHQGKLIFY VMTDKNFLLT YQILKNCTNE IIFKEYGIPV
190 200 210 220 230 240
IEPLLMSEEE ANSAEYDYNN DDDTLTVFDK NSSSRIIQNG FGITKEKGFL HFLSNQENID
250 260 270 280 290 300
ELPVKKLELR LKVVLKFDYE IIDMIGIKTF SKVGDGRYEE VLIVLFPHGL QILTISDFKV
310 320 330 340 350 360
SKSSLVEVKK GSKTIVCNKQ LMVLSHDSVE KQTIVSIIDI EKQAVEAIPL TDTPDELLTC
370 380 390 400 410 420
LEVNGYLVVV YKEKIICFDT RIKKVSHSWK PPFVIKLCDK INDKILLLVS EDSVNIHFYT
430 440 450 460 470 480
EFGNLLFATY FDEDDYNGDN NNDNSKDKNE KKAAEYKISD FVCLDKSLIT VSHSGKYQVW
490 500 510 520 530 540
KLWEEIKQTQ FDFRNPKCYV LTNTNNDVII YSPVTSSSIN NDNLQVIKLP TKTFNNHIAF
550 560 570 580 590 600
VKINSSLRLF ATYVSNKNIL LIHNLETNMW SSFADQNVLD LHWLGDNYLV CHMKNDDGST
610 620 630 640 650 660
NLKCLQIPLQ EANPDVELSD YVMWEYNVPE NTIVFSLHVN TLSRYKLLKM KSKNHNASEK
670 680 690 700 710 720
QPDALLKTAE IILVTDTQTI VFDVISTVHP CGLNIIKKFY QYLKINIPID VLPNKIEWII
730 740 750 760 770 780
NMKEGLLFFA DRKFIKLGKV DGGGWQTLTL LDNIEKIIDV IRDEIFVVQG HNYVVYSLED
790 800 810 820 830 840
LWDDKKPLVS IPIEEDLYPI STTPETATTH TLHCIFNARF SKLVVKHQIY LDQLILAKLE
850 860 870 880 890 900
DNTDLEDISH NYRFLKPYKF ALEKILSTKI LRSDSLDDIL KLIKMYDNTD PEHNISPPTH
910 920 930 940 950 960
SGMLEIISNC LRKIETKYWN HLFTNLKMTP RDLLALCIEE NEAKMLGVLL LVFLNYDEKD
970 980 990 1000 1010 1020
LGDDLHFKKS DLGTEESKAL NDNSTKKSEK SVTNLLKDEE LMLKVLELLV TSAANATDPI
1030 1040 1050
KATDSWDMCF QLIRLLKELD RENNTQLVQK ALERFK