AiPD: Autoinhibited Protein Database

Gene name	Slc13a5 (Nact)
Protein name	Na(+)/citrate cotransporter
Names	NaCT, Sodium-coupled citrate transporter, Sodium-dependent citrate transporter, Solute carrier family 13 member 5
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:237831
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

160-231 (Predicted disordered autoinhibitory region) PR

160-231 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q67BT3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs247215180	14	F>L	No	EVA
rs226854824	31	I>V	No	EVA
rs3389164226	32	P>S	No	EVA
rs3389139773	47	V>D	No	EVA
rs3389170400	67	F>Y	No	EVA
rs252225889	109	V>I	No	EVA
rs3389112836	120	K>N	No	EVA
rs3389174493	149	I>K	No	EVA
rs237022789	170	L>Q	No	EVA
rs217708309	181	T>A	No	EVA
rs220009343	187	S>N	No	EVA
rs26915262	195	N>S	No	EVA
rs3389190077	198	E>K	No	EVA
rs3389170420	223	G>D	No	EVA
rs3389176809	255	S>F	No	EVA
rs3389174495	257	F>C	No	EVA
rs3389139816	269	V>E	No	EVA
rs242215768	278	L>F	No	EVA
rs3389112832	278	L>S	No	EVA
rs3389175748	279	Y>*	No	EVA
rs257723785	302	A>V	No	EVA
rs3402411761	341	F>*	No	EVA
rs3402393562	348	F>DPGE*	No	EVA
rs236239133	356	V>I	No	EVA
rs3389171705	378	K>R	No	EVA
rs3389164254	382	N>K	No	EVA
rs3389179207	408	E>D	No	EVA
rs3389112827	420	G>E	No	EVA
rs3389175579	447	V>E	No	EVA
rs3389164183	458	C>*	No	EVA
rs3389175811	462	M>L	No	EVA
rs3389139789	472	T>S	No	EVA
rs3389175589	496	I>N	No	EVA
rs3389183524	540	G>V	No	EVA
rs3389151791	543	S>F	No	EVA
rs256064339	555	M>V	No	EVA
rs3389147807	561	F>Y	No	EVA
rs3389174507	562	P>L	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Sodium/sulphate symporter, conserved site	502 - 518	IPR031312

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
citrate transmembrane transporter activity	Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other.
identical protein binding	Binding to an identical protein or proteins.
organic acid:sodium symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).
sodium:dicarboxylate symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).
succinate transmembrane transporter activity	Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other.
tricarboxylic acid transmembrane transporter activity	Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups.

Name	Definition
alpha-ketoglutarate transport	The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
anion transmembrane transport	The process in which an anion is transported across a membrane.
cellular response to lithium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
citrate transport	The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
fumarate transport	The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
oxaloacetate transport	The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
succinate transport	The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
tricarboxylic acid transport	The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86YT5	SLC13A5	Na(+)/citrate cotransporter	Homo sapiens (Human)	PR
Q93655	nac-1	Sodium-dependent low-affinity dicarboxylate transporter 1	Caenorhabditis elegans	PR