Q66JV4
Gene name |
Rbm12b2 (Rbm12bb) |
Protein name |
RNA-binding protein 12B-B |
Names |
RNA-binding motif protein 12B-B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77604 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q66JV4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q66JV4-F1 | Predicted | AlphaFoldDB |
30 variants for Q66JV4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388669101 | 458 | A>D | No | EVA | |
| rs3388669120 | 458 | A>S | No | EVA | |
| rs582407139 | 486 | I>V | No | EVA | |
| rs247449048 | 530 | Y>* | No | EVA | |
| rs264772101 | 554 | C>R | No | EVA | |
| rs3388666382 | 554 | C>W | No | EVA | |
| rs3388673716 | 564 | E>* | No | EVA | |
| rs3388673362 | 564 | E>D | No | EVA | |
| rs583891249 | 568 | H>Y | No | EVA | |
| rs1134956266 | 574 | T>P | No | EVA | |
| rs3388670161 | 578 | R>K | No | EVA | |
| rs3388673168 | 583 | R>I | No | EVA | |
| rs3388673438 | 588 | D>V | No | EVA | |
| rs579754629 | 650 | A>T | No | EVA | |
| rs13475694 | 664 | I>T | No | EVA | |
| rs3388673219 | 693 | L>F | No | EVA | |
| rs583203051 | 700 | R>T | No | EVA | |
| rs3388673206 | 705 | E>D | No | EVA | |
| rs3388670327 | 705 | E>K | No | EVA | |
| rs3388673388 | 706 | F>L | No | EVA | |
| rs3388671263 | 721 | F>V | No | EVA | |
| rs227344926 | 737 | E>G | No | EVA | |
| rs3388663159 | 738 | N>K | No | EVA | |
| rs3388660122 | 743 | K>N | No | EVA | |
| rs3388663205 | 746 | P>T | No | EVA | |
| rs3388677143 | 747 | D>V | No | EVA | |
| rs255112691 | 756 | G>R | No | EVA | |
| rs3388670354 | 777 | F>L | No | EVA | |
| rs3388671259 | 808 | N>I | No | EVA | |
| rs27730044 | 814 | S>A | No | EVA |
No associated diseases with Q66JV4
5 regional properties for Q66JV4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SNF2, N-terminal | 413 - 657 | IPR000330 |
| domain | Helicase, C-terminal | 673 - 827 | IPR001650 |
| domain | HARP domain | 199 - 269 | IPR010003-1 |
| domain | HARP domain | 286 - 357 | IPR010003-2 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 391 - 564 | IPR014001 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of RNA splicing | Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVVIRLLGL | PFIAGPVDIR | HFFKGLTIPD | GGVHIIGGKV | GEAFIIFATD | EDARRAISRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGFIKDSSVE | LFLSSKVEMQ | KTIEMKRTAR | VGRGRPGSGA | SGVGNVYHFS | DALKEEESYS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GYGSSVNRDA | GFHTNGTGLD | LRPRKTRPLK | AENPYLFLRG | LPYLVNEDDV | RVFFSGLCVD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVILLKHHDG | RNNGDAIVKF | ASCVDASGGL | KCHRSFMGSR | FIEVMQGSEQ | QWIEFGGTAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EGGDTPRMRS | EEHSPSRRIN | GRHFRKRSHS | KSPRARSRSP | LGFYVHLKNL | SLNTNKRDLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLFRDTDLTN | DQIKFVYKDE | RRTRYAFVMF | KNQKDYNTAL | GLHKTVLQYR | PVLIDPVSRK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EMVRIIECYE | KKRPESLEKE | RPGRVSQKYS | QEGFSGSGQK | LCIYIRNLPF | DVTKGEVQKF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FADFSLVEDD | IYLLCDDKGV | GLGEALVRFK | SEEQAMKAER | LNRQRFLGIE | VLLRLISEEQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MQEFGIKSSW | LSNERTQACS | RSHDGDDCSC | LFDLKDPSSC | SFGQSESLRY | HPKDLRKMGH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FKHPQGYFRQ | SDRCSPEDFR | HSPEDYRHPW | EEHTSHSREE | DWRLPLEDWP | QEDDFRQCHE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KDHRQLRSPW | EEDFRRPSQE | HFRRSYQEHI | RRPPQEHFRR | SREEDFRHVA | DEDFRQASDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DFRISQEDLR | YPTDEDFRRV | SVEDLREVPE | KDLRLPKNFR | SSGEEFWTPP | DFRGQHPFVN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FDHLQGGKFD | FEKYKLENFH | DGKFVPDLKF | NCGSGGIIRV | MISNLPFKAN | ANEILDFFHG |
| 790 | 800 | 810 | 820 | 830 | |
| YKVIPDSVSI | QYNEEGLPLG | EAIVSMTNYN | EALSAVKDLS | GRPVGPRKVK | LSLL |