Q63009

PR
Gene name
Prmt1 (Hrmt1l2)
Protein name
Protein arginine N-methyltransferase 1
Names
Histone-arginine N-methyltransferase PRMT1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:60421
EC number
2.1.1.319: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q63009

Entry ID Method Resolution Chain Position Source
1OR8 X-ray 235 A A 14-353 PDB
1ORH X-ray 264 A A 1-353 PDB
1ORI X-ray 250 A A 11-353 PDB
3Q7E X-ray 220 A A 14-353 PDB
AF-Q63009-F1 Predicted AlphaFoldDB

No variants for Q63009

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63009

No associated diseases with Q63009

1 regional properties for Q63009

Type Name Position InterPro Accession
domain Methyltransferase domain 25 74 - 171 IPR041698

Functions

Description
EC Number 2.1.1.319 Methyltransferases
Subcellular Localization
  • Nucleus
  • Nucleus, nucleoplasm
  • Cytoplasm, cytosol
  • Cytoplasm
  • Lysosome membrane
  • Mostly found in the cytoplasm
  • Colocalizes with CHTOP within the nucleus
  • Low levels detected also in the chromatin fraction (By similarity)
  • Upon methionine stimulation, localizes to the lysosome in an NPRL2-dependent manner (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
methylosome A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

15 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
histone methyltransferase activity (H4-R3 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.
histone-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
identical protein binding Binding to an identical protein or proteins.
methyl-CpG binding Binding to a methylated cytosine/guanine dinucleotide.
mitogen-activated protein kinase p38 binding Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein.
protein-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
protein-arginine omega-N asymmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.
protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine
S-adenosyl-L-methionine binding +Binding to S-adenosyl-L-methionine.
S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
snoRNP binding Binding to a small nucleolar ribonucleoprotein particle.

19 GO annotations of biological process

Name Definition
cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
histone H4-R3 methylation The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone.
histone methylation The modification of histones by addition of methyl groups.
in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
liver regeneration The regrowth of lost or destroyed liver.
negative regulation of JNK cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
negative regulation of megakaryocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
peptidyl-arginine methylation The addition of a methyl group to an arginine residue in a protein.
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.
peptidyl-arginine omega-N-methylation The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
positive regulation of hemoglobin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
positive regulation of p38MAPK cascade Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9JIF0 Prmt1 Protein arginine N-methyltransferase 1 Mus musculus (Mouse) PR
Q5U4E8 Prmt7 Protein arginine N-methyltransferase 7 Rattus norvegicus (Rat) PR
Q7XKC0 PRMT6.1 Probable protein arginine N-methyltransferase 6.1 Oryza sativa subsp japonica (Rice) PR
Q6NWG4 prmt6 Protein arginine N-methyltransferase 6 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAAAEAANCI MEVSCGQAES SEKPNAEDMT SKDYYFDSYA HFGIHEEMLK DEVRTLTYRN
70 80 90 100 110 120
SMFHNRHLFK DKVVLDVGSG TGILCMFAAK AGARKVIGIE CSSISDYAVK IVKANKLDHV
130 140 150 160 170 180
VTIIKGKVEE VELPVEKVDI IISEWMGYCL FYESMLNTVL HARDKWLAPD GLIFPDRATL
190 200 210 220 230 240
YVTAIEDRQY KDYKIHWWEN VYGFDMSCIK DVAIKEPLVD VVDPKQLVTN ACLIKEVDIY
250 260 270 280 290 300
TVKVEDLTFT SPFCLQVKRN DYVHALVAYF NIEFTRCHKR TGFSTSPESP YTHWKQTVFY
310 320 330 340 350
MEDYLTVKTG EEIFGTIGMR PNAKNNRDLD FTIDLDFKGQ LCELSCSTDY RMR