Q62393
Gene name |
Tpd52 |
Protein name |
Tumor protein D52 |
Names |
mD52 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21985 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62393
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62393-F1 | Predicted | AlphaFoldDB |
17 variants for Q62393
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388623146 | 2 | E>V | No | EVA | |
| rs3388624463 | 4 | R>G | No | EVA | |
| rs3388623261 | 4 | R>K | No | EVA | |
| rs3388624441 | 7 | E>G | No | EVA | |
| rs3388619670 | 9 | A>S | No | EVA | |
| rs3388622270 | 35 | T>I | No | EVA | |
| rs585769604 | 45 | V>F | No | EVA | |
| rs3388617093 | 65 | S>C | No | EVA | |
| rs3392726957 | 114 | S>* | No | EVA | |
| rs3392623461 | 114 | S>* | No | EVA | |
| rs3392685953 | 114 | S>A | No | EVA | |
| rs3392726981 | 114 | S>T | No | EVA | |
| rs3388623688 | 135 | Y>* | No | EVA | |
| rs3388614495 | 153 | F>L | No | EVA | |
| rs3388614557 | 202 | N>Y | No | EVA | |
| rs13468776 | 211 | M>I | No | EVA | |
| rs245810403 | 220 | M>T | No | EVA |
No associated diseases with Q62393
No regional properties for Q62393
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q62393 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell differentiation | The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P55327 | TPD52 | Tumor protein D52 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MECRDMELAD | DYQSPFDFDS | GVNKNYLYLS | PSGNTSPPGS | PTQNVGLLKT | EPVAEEGEDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTMLSAPEAL | TEEEQEELRR | ELTKVEEEIQ | TLSQVLAAKE | KHLAELKRKL | GISSLQEFKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NIAKGWQDVT | ATNAYKKTSE | TLSQAGQKAS | AAFSSVGSVI | TKKLEDVKNS | PTFKSFEEKV |
| 190 | 200 | 210 | 220 | ||
| ENLKSKVGGA | KPAGGDFGEV | LNSTANATST | MTTEPPPEQM | TESP |