AiPD: Autoinhibited Protein Database

P55327

Gene name	TPD52
Protein name	Tumor protein D52
Names	Protein N8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7163
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-224 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

2-224 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P55327

Entry ID	Method	Resolution	Chain	Position	Source
AF-P55327-F1	Predicted				AlphaFoldDB

162 variants for P55327

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA4790378 rs746736990	2	D>G		No	ClinGen ExAC gnomAD
rs1212557390 CA371519112	6	M>R		No	ClinGen TOPMed
CA4790375 rs745403299	6	M>V		No	ClinGen ExAC gnomAD
CA4790374 rs778519039	7	D>N		No	ClinGen ExAC gnomAD
rs1463791265 CA371519073	9	Y>*		No	ClinGen gnomAD
CA4790372 rs117461662	9	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	9	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA180352605 rs148140891	10	E>A		No	ClinGen ESP gnomAD
rs753684914 CA371519023	12	Y>C		No	ClinGen ExAC gnomAD
rs753684914 CA4790371	12	Y>F		No	ClinGen ExAC gnomAD
TCGA novel	13	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs879432745 CA180352601	13	Q>E		No	ClinGen gnomAD
CA4790370 rs201398738	13	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs752479576 CA4790368	15	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	16	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371518970 rs1179179138	18	F>L		No	ClinGen gnomAD
rs868160953 CA180352550	18	F>S		No	ClinGen gnomAD
CA4790366 rs759711286	19	D>V		No	ClinGen ExAC gnomAD
rs1202894472 CA371518947	22	V>A		No	ClinGen gnomAD
CA180352527 rs750843868	23	N>K		No	ClinGen gnomAD
CA180352520 rs908287572	27	L>R		No	ClinGen TOPMed
rs766421047 CA4790364	28	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA371518883 rs1195708759	31	P>L		No	ClinGen gnomAD
TCGA novel	31	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1308622516 CA371518874	33	G>*		No	ClinGen TOPMed gnomAD
rs1308622516 CA371518873	33	G>R		No	ClinGen TOPMed gnomAD
rs1563608754 CA371518864	34	N>S		No	ClinGen Ensembl
rs1391635707 CA371518866	34	N>Y		No	ClinGen gnomAD
CA371518843 rs1307773689	37	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs762093515 CA371518838	38	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762093515 CA4790360	38	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1267898558 CA371518840	38	P>S		No	ClinGen gnomAD
rs147106951 CA4790358	39	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	40	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371518829 rs1366815799	40	S>L		No	ClinGen gnomAD
CA4790357 rs369122924	42	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA371518811 rs1419932471	43	L>P		No	ClinGen gnomAD
CA371518808 rs1563608668	44	Q>E		No	ClinGen Ensembl
TCGA novel	44	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778609050 CA4790356	45	K>Q		No	ClinGen ExAC gnomAD
CA371516056 rs1228817011	47	G>V		No	ClinGen TOPMed gnomAD
CA180342200 rs994094559	48	L>V		No	ClinGen TOPMed
rs35099105 CA4790326 VAR_061860	52	D>Y		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4790324 rs765338899	54	V>F		No	ClinGen ExAC TOPMed gnomAD
rs1333837243 CA371515983	55	P>S		No	ClinGen gnomAD
CA4790322 rs754394019	56	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1398382383 CA371515971	56	E>G		No	ClinGen gnomAD
CA4790323 rs35584545	56	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs137978415 CA4790321	57	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4790320 rs761133445	58	G>E		No	ClinGen ExAC gnomAD
rs750865439	59	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA180342141 rs1012384818	60	D>G		No	ClinGen Ensembl
CA371515899 rs1444780919	62	A>D		No	ClinGen gnomAD
CA4790318 rs775926920	64	T>M		No	ClinGen ExAC TOPMed gnomAD
rs201546255 CA180342130	66	S>G		No	ClinGen Ensembl
CA371515851 rs1184974005	67	A>S		No	ClinGen gnomAD
rs1586199613 CA371515815	70	T>N		No	ClinGen Ensembl
rs1440998419 CA371515810	71	L>F		No	ClinGen gnomAD
rs765975051 CA4790317	71	L>P		No	ClinGen ExAC gnomAD
CA4790315 rs150326619 COSM1101889	72	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA371515796 rs150326619	72	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	73	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371515759 rs1273176991	75	E>G		No	ClinGen gnomAD
CA371515766 rs1453950680	75	E>K		No	ClinGen TOPMed
rs1248259559 CA371515752	76	Q>E		No	ClinGen TOPMed gnomAD
CA371515745 rs1259414128	76	Q>R		No	ClinGen gnomAD
CA4790314 rs769315107	78	E>*		No	ClinGen ExAC gnomAD
rs748148121 CA4790313	79	L>P		No	ClinGen ExAC gnomAD
rs1260938418 COSM1101887 CA371515677 COSM1101888	82	E>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs776564816 CA4790312	82	E>G		No	ClinGen ExAC gnomAD
CA371515665 rs1337272376	83	L>F		No	ClinGen TOPMed gnomAD
CA4790310 rs746837975	84	A>G		No	ClinGen ExAC TOPMed gnomAD
CA4790311 rs768515340	84	A>T		No	ClinGen ExAC gnomAD
CA180342060 rs746837975	84	A>V		No	ClinGen ExAC TOPMed gnomAD
CA371519735 rs1416003851	86	V>I		No	ClinGen gnomAD
CA180374666 rs867295433	88	E>Q		No	ClinGen Ensembl
rs1586166102 CA371519679	94	S>P		No	ClinGen Ensembl
CA4790283 rs749406995	96	V>A		No	ClinGen ExAC gnomAD
rs756734597 CA4790281	98	A>T		No	ClinGen ExAC gnomAD
CA371519629 rs1268934416	101	E>D		No	ClinGen gnomAD
rs201667286 CA4790278	104	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200095834 CA4790277	105	A>E		No	ClinGen 1000Genomes ExAC gnomAD
rs200095834 CA4790276	105	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA371519597 rs1284923324	106	E>D		No	ClinGen gnomAD
CA371519595 rs1586165887	107	I>L		No	ClinGen Ensembl
CA4790275 rs761407263	108	K>R		No	ClinGen ExAC gnomAD
CA4790272 rs760676128	109	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4790273 rs146733856	109	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1388750878 CA371519578	110	K>Q		No	ClinGen gnomAD
rs1304130226 CA371519568	111	L>F		No	ClinGen TOPMed
CA371519559 rs1586165770	112	G>V		No	ClinGen Ensembl
CA371519557 rs1455345174	113	I>V		No	ClinGen gnomAD
rs200499338 CA4790270	114	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200499338 CA4790271	114	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA371519518 rs771297143	119	L>I		No	ClinGen ExAC TOPMed gnomAD
rs11542215 CA180374557	120	K>R		No	ClinGen Ensembl
CA4790266 rs749499055	121	Q>*		No	ClinGen ExAC
CA4790265 rs778038890	124	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	127	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769988218 CA4790264	127	W>R		No	ClinGen ExAC gnomAD
rs368062879 CA180374531	130	V>M		No	ClinGen gnomAD
rs934302458 CA180374527	131	T>I		No	ClinGen Ensembl
rs1463694731 CA371519431	132	A>T		No	ClinGen gnomAD
rs781725707 CA4790262	134	S>F		No	ClinGen ExAC gnomAD
CA4790261 rs755401926	135	A>S		No	ClinGen ExAC gnomAD
CA4790260 rs747424217	135	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4790237 rs777409925	137	K>Q		No	ClinGen ExAC gnomAD
CA180373607 rs887960401	137	K>R		No	ClinGen Ensembl
TCGA novel	140	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	146	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA180373603 rs267602013	147	G>R		No	ClinGen Ensembl
rs1434619455 CA371519311	149	K>E		No	ClinGen TOPMed
CA371519306 rs1272095512	149	K>T		No	ClinGen TOPMed
CA4790235 rs752271258	152	A>V		No	ClinGen ExAC gnomAD
rs374002443 CA4790234	155	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4790233 rs141089311	155	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs202240755 CA4790231	156	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs747560761 CA4790230	157	V>I		No	ClinGen ExAC TOPMed gnomAD
CA371519247 rs1251874216	159	S>L		No	ClinGen TOPMed
rs773103313 CA4790229	160	V>I		No	ClinGen ExAC TOPMed gnomAD
rs765579452 COSM1230140 CA4790228 COSM1230139	162	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs761919845 CA4790227	162	T>I		No	ClinGen ExAC gnomAD
TCGA novel	164	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1321127651 CA371518479	170	N>K		No	ClinGen gnomAD
rs1458458259 CA371518475	171	S>P		No	ClinGen gnomAD
CA371518415 rs1355751635	176	S>L		No	ClinGen TOPMed
TCGA novel	178	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752907528 CA4790168	182	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA180368866 rs866253870	185	K>R		No	ClinGen Ensembl
CA180365824 rs966277347	186	S>T		No	ClinGen TOPMed gnomAD
CA180365812 rs1019589445	188	V>I		No	ClinGen TOPMed
TCGA novel	189	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs986317426 CA180365802	191	T>S		No	ClinGen TOPMed
rs1586121447 CA371517117	193	P>H		No	ClinGen Ensembl
CA4790151 rs773865208	196	G>V		No	ClinGen ExAC gnomAD
CA371517001 rs1296356215	199	G>V		No	ClinGen gnomAD
CA4790148 rs777491282	200	E>G		No	ClinGen ExAC gnomAD
rs749215143 CA4790150	200	E>K		No	ClinGen ExAC gnomAD
rs749215143 CA4790149	200	E>Q		No	ClinGen ExAC gnomAD
rs747879668 CA4790146	203	N>D		No	ClinGen ExAC gnomAD
CA371516934 rs1375298567	203	N>I		No	ClinGen gnomAD
CA4790145 rs781396350	204	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs994960105 CA180365758	206	A>G		No	ClinGen TOPMed
CA371516891 rs1471463776	206	A>S		No	ClinGen TOPMed
rs897894378 CA180365747	207	N>I		No	ClinGen TOPMed
CA371516861 rs534297357	208	A>G		No	ClinGen ExAC TOPMed gnomAD
CA4790142 rs534297357	208	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4790141 rs758896480	209	S>N		No	ClinGen ExAC gnomAD
rs933931448 CA180365695	209	S>R		No	ClinGen Ensembl
rs1329734595 CA371516837	210	A>V		No	ClinGen TOPMed
CA371516825 rs1335581320	211	T>A		No	ClinGen TOPMed
CA4790138 rs762276312	212	T>A		No	ClinGen ExAC gnomAD
CA4790137 rs373612910	213	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs373612910 CA180365673	213	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs759207656 CA4790135	214	E>G		No	ClinGen ExAC gnomAD
rs770468798 CA4790133	215	P>R		No	ClinGen ExAC gnomAD
rs773143608 CA4790131	216	L>P		No	ClinGen ExAC gnomAD
rs1481299394 CA371516709	221	Q>E		No	ClinGen TOPMed
rs1481299394 CA371516710	221	Q>K		No	ClinGen TOPMed
rs769652694 CA4790130	222	E>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	222	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377167805 CA4790129	223	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with P55327

No regional properties for P55327

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P55327

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
protein homodimerization activity	Binding to an identical protein to form a homodimer.

3 GO annotations of biological process

Name	Definition
anatomical structure morphogenesis	The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
B cell differentiation	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
secretion	The controlled release of a substance by a cell or a tissue.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q62393	Tpd52	Tumor protein D52	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MDCREMDLYE	DYQSPFDFDA	GVNKSYLYLS	PSGNSSPPGS	PTLQKFGLLR	TDPVPEEGED
70	80	90	100	110	120
VAATISATET	LSEEEQEELR	RELAKVEEEI	QTLSQVLAAK	EKHLAEIKRK	LGINSLQELK
130	140	150	160	170	180
QNIAKGWQDV	TATSAYKKTS	ETLSQAGQKA	SAAFSSVGSV	ITKKLEDVKN	SPTFKSFEEK
190	200	210	220
VENLKSKVGG	TKPAGGDFGE	VLNSAANASA	TTTEPLPEKT	QESL