Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62203
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62203-F1 | Predicted | AlphaFoldDB |
No variants for Q62203
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62203 | |||||
No associated diseases with Q62203
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U2 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
| U2-type prespliceosome | A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. |
| U2-type spliceosomal complex | Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| nucleic acid binding | Binding to a nucleic acid. |
| zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| RNA splicing, via transesterification reactions | Splicing of RNA via a series of two transesterification reactions. |
| spliceosomal complex assembly | The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. |
| U2-type prespliceosome assembly | The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFQHRPGGK | TGSGGVASSS | ESNRDRRERL | RQLALETIDI | NKDPYFMKNH | LGSYECKLCL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLHNNEGSYL | AHTQGKKHQT | NLARRAAKEA | KEAPAQPAPE | QVKVEVKKFV | KIGRPGYKVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQRDTEMGQQ | SLLFQIDYPE | IAEGIMPRHR | FMSAYEQRIE | PPDRRWQYLL | MAAEPYETIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FKVPSREIDK | AEGKFFFLQF | HFKMEKPPAP | PSLPAGPPGV | KRPPPPLMNG | LPPRPPLPDA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPPPPPGGLP | LPPMPPTGPA | PSGPPGPPQM | PPPAPGVHPP | APVVHPPTSG | VHPPAPGVHP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PAPVVHPPTS | GVHPPAPGVH | PPTPGVHPPA | PGVHPPAPGV | HPPAPGVHPP | TPGVHPPAPG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VHPPAPGVHP | PAPGVHPPPS | AGVHPQAPGV | HPPAPAVHPQ | APGVHPPAPG | IHPQAPGVHP |
| 430 | 440 | 450 | 460 | 470 | |
| QPPPGVHPAA | PGVHPQPPGV | HPSNPGVHPA | PMPPMLRPPL | PSDGPGNMPP | PPPGN |