A5PJN8

PR
Gene name
SF3A2
Protein name
Splicing factor 3A subunit 2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:789082
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5PJN8

Entry ID Method Resolution Chain Position Source
AF-A5PJN8-F1 Predicted AlphaFoldDB

151 variants for A5PJN8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs473860112 2 D>E No EVA
rs444072268 10 K>N No EVA
rs456048030 11 T>N No EVA
rs439722519 13 S>G No EVA
rs458183681 15 G>R No EVA
rs440731748 16 V>G No EVA
rs480619632 21 E>A No EVA
rs450932876 25 D>H No EVA
rs440847448 28 E>V No EVA
rs469432345 31 R>G No EVA
rs478301928 36 E>A No EVA
rs445052062 37 T>S No EVA
rs454374281 53 S>Y No EVA
rs436354040 54 Y>* No EVA
rs454777309 61 T>P No EVA
rs454777309 61 T>S No EVA
rs476507558 63 H>Q No EVA
rs443730667 65 N>S No EVA
rs477166286 75 G>E No EVA
rs433087045 87 A>P No EVA
rs451175499 88 K>R No EVA
rs455389160 102 V>D No EVA
rs440012792 102 V>L No EVA
rs442127834 105 E>A No EVA
rs473711178 105 E>Q No EVA
rs463836757 106 V>G No EVA
rs482316362 107 K>T No EVA
rs439922379 109 F>C No EVA
rs458045560 112 I>T No EVA
rs479829710 117 Y>* No EVA
rs446823859 118 K>N No EVA
rs482718181 152 M>L No EVA
rs443525295 175 P>R No EVA
rs474570347 183 V>G No EVA
rs463409039 186 R>K No EVA
rs481972666 186 R>S No EVA
rs452953870 200 N>S No EVA
rs459186711 202 E>A No EVA
rs453200446 207 F>S No EVA
rs474903423 208 L>P No EVA
rs441599407 210 F>L No EVA
rs456967619 211 H>P No EVA
rs456967619 211 H>R No EVA
rs475503608 212 F>L No EVA
rs439312590 214 M>R No EVA
rs459064182 215 E>A No EVA
rs459839181 216 K>M No EVA
rs481566726 216 K>N No EVA
rs441373985 216 K>Q No EVA
rs459839181 216 K>T No EVA
rs482363994 219 A>P No EVA
rs434533427 222 S>R No EVA
rs464646532 222 S>T No EVA
rs468459876 225 A>G No EVA
rs475476654 228 P>R No EVA
rs451351828 229 G>V No EVA
rs459826644 230 V>G No EVA
rs441359994 230 V>L No EVA
rs481501628 231 K>I No EVA
rs442311999 231 K>N No EVA
rs464039385 232 R>Q No EVA
rs479949737 237 L>R No EVA
rs435463126 238 M>I No EVA
rs446658977 238 M>L No EVA
rs468398173 238 M>R No EVA
rs450782263 239 N>I No EVA
rs469273089 239 N>K No EVA
rs450782263 239 N>T No EVA
rs432730801 240 G>A No EVA
rs451237143 241 L>P No EVA
rs451237143 241 L>R No EVA
rs133173310 244 R>P No EVA
rs134550715 259 L>R No EVA
rs442199167 276 G>A No EVA
rs464016548 279 Q>H No EVA
rs474706007 280 L>M No EVA
rs439572884 287 V>G No EVA
rs458113033 288 H>P No EVA
rs479886258 289 P>A No EVA
rs446997968 295 H>P No EVA
rs480383113 297 P>T No EVA
rs450599512 301 V>E No EVA
rs469298474 303 P>R No EVA
rs433125868 304 P>T No EVA
rs444809119 308 V>D No EVA
rs466440266 316 H>P No EVA
rs433568953 318 P>Q No EVA
rs473706946 320 P>Q No EVA
rs457505964 322 V>A No EVA
rs476144743 323 H>N No EVA
rs439919320 324 P>A No EVA
rs473358421 325 P>Q No EVA
rs440453811 326 A>E No EVA
rs462192262 327 S>A No EVA
rs462754860 329 V>G No EVA
rs450666184 329 V>I No EVA
rs478134233 330 H>P No EVA
rs445058798 331 P>T No EVA
rs466728027 335 G>R No EVA
rs467292549 336 V>D No EVA
rs448806850 336 V>F No EVA
rs437731799 337 H>N No EVA
rs457514714 337 H>P No EVA
rs469591390 338 P>S No EVA
rs469591390 338 P>T No EVA
rs473693662 340 A>P No EVA
rs455779211 341 P>A No EVA
rs474275510 341 P>R No EVA
rs444528223 342 G>E No EVA
rs478027698 343 V>G No EVA
rs438587704 344 H>P No EVA
rs467229129 348 P>R No EVA
rs449666429 350 V>D No EVA
rs449666429 350 V>G No EVA
rs451931126 351 H>P No EVA
rs433324602 351 H>Y No EVA
rs467267250 354 A>T No EVA
rs434296865 357 V>G No EVA
rs455714014 358 H>L No EVA
rs455714014 358 H>R No EVA
rs444447153 364 G>D No EVA
rs456523945 366 H>P No EVA
rs471923943 371 V>A No EVA
rs460222366 372 V>G No EVA
rs438577747 372 V>L No EVA
rs478690955 373 H>P No EVA
rs461096974 375 P>S No EVA
rs482656041 380 H>L No EVA
rs482656041 380 H>P No EVA
rs482656041 380 H>R No EVA
rs449665764 384 P>Q No EVA
rs458533601 385 G>V No EVA
rs876223110 386 V>G No EVA
rs477177026 386 V>M No EVA
rs467204138 387 H>L No EVA
rs467204138 387 H>P No EVA
rs434184358 387 H>Q No EVA
rs449577391 389 T>P No EVA
rs437948100 391 A>G No EVA
rs468098171 391 A>S No EVA
rs437948100 391 A>V No EVA
rs471873233 392 V>I No EVA
rs453763208 393 H>P No EVA
rs472169019 394 P>L No EVA
rs479563559 395 Q>H No EVA
rs442596649 395 Q>K No EVA
rs461155514 395 Q>P No EVA
rs476551239 396 A>P No EVA
rs437342873 466 G>A No EVA
rs465645878 469 N>K No EVA
rs466090423 476 T>P No EVA

No associated diseases with A5PJN8

3 regional properties for A5PJN8

Type Name Position InterPro Accession
domain Matrin/U1-C, C2H2-type zinc finger 54 - 84 IPR000690
domain Matrin/U1-C-like, C2H2-type zinc finger 51 - 85 IPR003604
domain SF3A2 domain 112 - 206 IPR031781

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.
U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.

2 GO annotations of molecular function

Name Definition
nucleic acid binding Binding to a nucleic acid.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
U2-type prespliceosome assembly The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15428 SF3A2 Splicing factor 3A subunit 2 Homo sapiens (Human) PR
Q62203 Sf3a2 Splicing factor 3A subunit 2 Mus musculus (Mouse) PR
Q6AXT8 Sf3a2 Splicing factor 3A subunit 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL
70 80 90 100 110 120
TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT
130 140 150 160 170 180
KQRDTEMGQQ SLLFQIDYPE IAEGIMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA
190 200 210 220 230 240
FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG
250 260 270 280 290 300
LPPRPPLPES LPPPPPGGLP LPPMPPSGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG
310 320 330 340 350 360
VHPPAPGVHP PAPGVHPPAP VVHPPASGVH PPAPGVHPPA PGVHPPAPGV HPPAPGVHPP
370 380 390 400 410 420
PSAGVHPQAP VVHPPAPAVH PQAPGVHPTP AVHPQAPGVH PPAPGVHPPA PGIHPQPPGV
430 440 450 460 470
HPPPPGVHPP APGVHPQPPG VHPSNPGVHP PTPMPPMLRP PLPSEGPGNI PPPPPTN