Q61586

PR
Gene name
Gpam
Protein name
Glycerol-3-phosphate acyltransferase 1, mitochondrial
Names
GPAT-1, P90
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14732
EC number
2.3.1.15: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

655-724 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61586

Entry ID Method Resolution Chain Position Source
AF-Q61586-F1 Predicted AlphaFoldDB

30 variants for Q61586

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389555936 144 A>V No EVA
rs3389559429 158 Q>R No EVA
rs3389541250 162 A>V No EVA
rs3408323089 166 V>M No EVA
rs3389561509 180 T>N No EVA
rs3389455529 221 N>S No EVA
rs3389503850 230 H>D No EVA
rs3409409046 241 F>L No EVA
rs3409293579 242 I>S No EVA
rs261466571 263 V>I No EVA
rs3389513842 301 V>I No EVA
rs3389555937 404 F>Y No EVA
rs259523607 419 S>P No EVA
rs3409453001 484 S>C No EVA
rs3389559416 495 R>I No EVA
rs3389513830 505 L>H No EVA
rs3389513788 506 V>L No EVA
rs3389546863 520 D>Y No EVA
rs3389556002 549 T>R No EVA
rs3389556015 560 S>N No EVA
rs213903349 675 Q>P No EVA
rs3389540695 680 L>P No EVA
rs244554578 682 E>A No EVA
rs227383648 684 N>S No EVA
rs232705317 704 Y>H No EVA
rs3408323141 721 Q>L No EVA
rs3389547694 732 S>R No EVA
rs3389546432 736 I>F No EVA
rs864266855 799 V>E No EVA
rs3389547664 806 S>N No EVA

No associated diseases with Q61586

3 regional properties for Q61586

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 216 - 357 IPR002123
domain GPAT/DHAPAT, acyltransferase domain 201 - 411 IPR041728
domain GPAT/DHAPAT, C-terminal domain 366 - 814 IPR045520

Functions

Description
EC Number 2.3.1.15 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Mitochondrion outer membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate.

24 GO annotations of biological process

Name Definition
activated T cell proliferation The expansion of a T cell population following activation by an antigenic stimulus.
activation-induced cell death of T cells A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
acyl-CoA metabolic process The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
fatty acid homeostasis Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.
glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
negative regulation of activation-induced cell death of T cells Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
phospholipid homeostasis Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
positive regulation of activated T cell proliferation Any process that activates or increases the rate or extent of activated T cell proliferation.
positive regulation of multicellular organism growth Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
positive regulation of triglyceride biosynthetic process Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine.
response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
triglyceride metabolic process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P98192 Gnpat Dihydroxyacetone phosphate acyltransferase Mus musculus (Mouse) PR
10 20 30 40 50 60
MEESSVTVGT IDVSYLPSSS EYSLGRCKHT SEDWVDCGFK PTFFRSATLK WKESLMSRKR
70 80 90 100 110 120
PFVGRCCYSC TPQSWERFFN PSIPSLGLRN VIYINETHTR HRGWLARRLS YILFVQERDV
130 140 150 160 170 180
HKGMFATSVT ENVLSSSRVQ EAIAEVAAEL NPDGSAQQQS KAIQKVKRKA RKILQEMVAT
190 200 210 220 230 240
VSPGMIRLTG WVLLKLFNSF FWNIQIHKGQ LEMVKAATET NLPLLFLPVH RSHIDYLLLT
250 260 270 280 290 300
FILFCHNIKA PYIASGNNLN IPVFSTLIHK LGGFFIRRRL DETPDGRKDI LYRALLHGHV
310 320 330 340 350 360
VELLRQQQFL EIFLEGTRSR SGKTSCARAG LLSVVVDTLS SNTIPDILVI PVGISYDRII
370 380 390 400 410 420
EGHYNGEQLG KPKKNESLWS VARGVIRMLR KNYGYVRVDF AQPFSLKEYL EGQSQKPVSA
430 440 450 460 470 480
PLSLEQALLP AILPSRPNDV ADEHQDLSSN ESRNPADEAF RRRLIANLAE HILFTASKSC
490 500 510 520 530 540
AIMSTHIVAC LLLYRHRQGI HLSTLVEDFF VMKEEVLARD FDLGFSGNSE DVVMHAIQLL
550 560 570 580 590 600
GNCVTITHTS RKDEFFITPS TTVPSVFELN FYSNGVLHVF IMEAIIACSI YAVLNKRCSG
610 620 630 640 650 660
GSAGGLGNLI SQEQLVRKAA SLCYLLSNEG TISLPCQTFY QVCHETVGKF IQYGILTVAE
670 680 690 700 710 720
QDDQEDVSPG LAEQQWDKKL PELNWRSDEE DEDSDFGEEQ RDCYLKVSQS KEHQQFITFL
730 740 750 760 770 780
QRLLGPLLEA YSSAAIFVHN FSGPVPESEY LQKLHRYLIT RTERNVAVYA ESATYCLVKN
790 800 810 820
AVKMFKDIGV FKETKQKRVS VLELSSTFLP QCNRQKLLEY ILSFVVL