Q61559
Gene name |
Fcgrt (Fcrn) |
Protein name |
IgG receptor FcRn large subunit p51 |
Names |
FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14132 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61559
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61559-F1 | Predicted | AlphaFoldDB |
13 variants for Q61559
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs255698025 | 40 | T>M | No | EVA | |
| rs3413077280 | 41 | G>R | No | EVA | |
| 73 | M>V | strain: FVB/N [UniProt] | No | ||
| rs3388887010 | 91 | S>N | No | EVA | |
| rs38969339 | 111 | Y>F | strain: P/J [UniProt] | No | EVA |
| rs238895290 | 180 | N>S | No | EVA | |
| rs3388906022 | 185 | R>* | No | EVA | |
| rs3388904938 | 222 | A>T | No | EVA | |
| rs3388908669 | 270 | E>G | No | EVA | |
| rs3388905945 | 301 | V>I | No | EVA | |
| rs3388908736 | 323 | R>K | No | EVA | |
| rs230084773 | 361 | F>S | No | EVA | |
| rs213169474 | 363 | A>G | No | EVA |
No associated diseases with Q61559
4 regional properties for Q61559
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Immunoglobulin/major histocompatibility complex, conserved site | 273 - 279 | IPR003006 |
| domain | Immunoglobulin C1-set | 214 - 285 | IPR003597 |
| domain | Immunoglobulin-like domain | 202 - 289 | IPR007110 |
| domain | MHC class I-like antigen recognition-like | 27 - 197 | IPR011161 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-2-microglobulin binding | Binding to beta-2-microglobulin. |
| IgG binding | Binding to an immunoglobulin of an IgG isotype. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGMPLPWALS | LLLVLLPQTW | GSETRPPLMY | HLTAVSNPST | GLPSFWATGW | LGPQQYLTYN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLRQEADPCG | AWMWENQVSW | YWEKETTDLK | SKEQLFLEAL | KTLEKILNGT | YTLQGLLGCE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LASDNSSVPT | AVFALNGEEF | MKFNPRIGNW | TGEWPETEIV | ANLWMKQPDA | ARKESEFLLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SCPERLLGHL | ERGRRNLEWK | EPPSMRLKAR | PGNSGSSVLT | CAAFSFYPPE | LKFRFLRNGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASGSGNCSTG | PNGDGSFHAW | SLLEVKRGDE | HHYQCQVEHE | GLAQPLTVDL | DSSARSSVPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VGIVLGLLLV | VVAIAGGVLL | WGRMRSGLPA | PWLSLSGDDS | GDLLPGGNLP | PEAEPQGANA |
| FPATS |