P13599

PR
Gene name
Fcgrt (Fcrn)
Protein name
IgG receptor FcRn large subunit p51
Names
N-CAM-1, NCAM-1, N-CAM-1, NCAM-1, N-CAM-1, NCAM-1, ICAM-1, MALA-2, MyD10, ICAM-2, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29558
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

172-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P13599

Entry ID Method Resolution Chain Position Source
1FRT X-ray 450 A A 23-291 PDB
1I1A X-ray 280 A A 23-291 PDB
3FRU X-ray 220 A A/C/E 23-291 PDB
AF-P13599-F1 Predicted AlphaFoldDB

No variants for P13599

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P13599

No associated diseases with P13599

8 regional properties for P13599

Type Name Position InterPro Accession
domain SH3 domain 156 - 215 IPR001452-1
domain SH3 domain 226 - 285 IPR001452-2
domain Phox homology 4 - 125 IPR001683
domain Neutrophil cytosol factor 1, C-terminal 357 - 389 IPR015039
domain Neutrophil cytosol factor 1, PBR/AIR 282 - 331 IPR032136
domain Neutrophil cytosol factor 1, PX domain 6 - 123 IPR034909
domain Neutrophil cytosol factor 1, first SH3 domain 160 - 212 IPR035756
domain Neutrophil cytosol factor 1, second SH3 domain 230 - 282 IPR035757

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Endosome membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endosome membrane The lipid bilayer surrounding an endosome.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
beta-2-microglobulin binding Binding to beta-2-microglobulin.
IgG binding Binding to an immunoglobulin of an IgG isotype.
IgG receptor activity Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
humoral immune response An immune response mediated through a body fluid.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P55899 FCGRT IgG receptor FcRn large subunit p51 Homo sapiens (Human) PR
Q61559 Fcgrt IgG receptor FcRn large subunit p51 Mus musculus (Mouse) PR
Q63493 Cd1d Antigen-presenting glycoprotein CD1d Rattus norvegicus (Rat) PR
O35799 Hfe Hereditary hemochromatosis protein homolog Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGMSQPGVLL SLLLVLLPQT WGAEPRLPLM YHLAAVSDLS TGLPSFWATG WLGAQQYLTY
70 80 90 100 110 120
NNLRQEADPC GAWIWENQVS WYWEKETTDL KSKEQLFLEA IRTLENQING TFTLQGLLGC
130 140 150 160 170 180
ELAPDNSSLP TAVFALNGEE FMRFNPRTGN WSGEWPETDI VGNLWMKQPE AARKESEFLL
190 200 210 220 230 240
TSCPERLLGH LERGRQNLEW KEPPSMRLKA RPGNSGSSVL TCAAFSFYPP ELKFRFLRNG
250 260 270 280 290 300
LASGSGNCST GPNGDGSFHA WSLLEVKRGD EHHYQCQVEH EGLAQPLTVD LDSPARSSVP
310 320 330 340 350 360
VVGIILGLLL VVVAIAGGVL LWNRMRSGLP APWLSLSGDD SGDLLPGGNL PPEAEPQGVN
AFPATS