Q61168

PR
Gene name
Laptm5
Protein name
Lysosomal-associated transmembrane protein 5
Names
Lysosomal-associated multitransmembrane protein 5, Retinoic acid-inducible E3 protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:16792
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

195-261 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61168

Entry ID Method Resolution Chain Position Source
AF-Q61168-F1 Predicted AlphaFoldDB

7 variants for Q61168

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388717279 6 A>T No EVA
rs3388713843 119 A>S No EVA
rs3388721082 126 P>L No EVA
rs3388723375 161 L>F No EVA
rs3388717299 198 L>V No EVA
rs3388718814 246 P>L No EVA
rs3388714813 259 S>P No EVA

No associated diseases with Q61168

No regional properties for Q61168

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q61168

Functions

Description
EC Number
Subcellular Localization
  • Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

4 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
protein sequestering activity Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin-dependent protein binding Binding to a protein upon ubiquitination of the target protein.

28 GO annotations of biological process

Name Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
defense response to tumor cell Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
Golgi to lysosome transport The directed movement of substances from the Golgi to lysosomes.
induction of programmed cell death A process which directly activates any of the steps required for programmed cell death.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
negative regulation of activated T cell proliferation Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
negative regulation of autophagic cell death Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.
negative regulation of B cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
negative regulation of interferon-gamma production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
negative regulation of pre-B cell receptor expression Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells.
negative regulation of T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
negative regulation of T cell receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
positive regulation of cytokine production involved in immune response Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
positive regulation of lysosomal membrane permeability Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.
positive regulation of macrophage cytokine production Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of NIK/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
positive regulation of proteolysis involved in protein catabolic process Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.
positive regulation of receptor catabolic process Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
positive regulation of tumor necrosis factor-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.
positive regulation of ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
protein localization to lysosome A process in which a protein is transported to, or maintained in, a location within a lysosome.
protein targeting to lysosome The process of directing proteins towards the lysosome using signals contained within the protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJA5 LAPTM5 Lysosomal-associated transmembrane protein 5 Bos taurus (Bovine) PR
Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 Homo sapiens (Human) PR
10 20 30 40 50 60
MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC RFFKMPYLRM
70 80 90 100 110 120
ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI MDFLLCLLTL LGSYIELPAY
130 140 150 160 170 180
LKLARPRPGP SKVPLMTLQL LDFCLSILTL CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH
190 200 210 220 230 240
SQFINMMLIF SVAFITVLIL KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE
250 260
ALSLPPKTPE GDPAPPPYSE V