AiPD: Autoinhibited Protein Database

Q13571

Gene name	LAPTM5 (KIAA0085)
Protein name	Lysosomal-associated transmembrane protein 5
Names	Lysosomal-associated multitransmembrane protein 5, Retinoic acid-inducible E3 protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7805
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

194-262 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

194-262 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q13571

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q13571-F1	Predicted				AlphaFoldDB

217 variants for Q13571

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1325841150	1	M>?	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1569882005 CA339541341	2	D>A		No	ClinGen Ensembl
rs143486131 CA728228	4	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143486131 CA728229	4	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728226 rs146490774	4	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728227 rs146490774	4	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728225 rs773649946	6	S>Y		No	ClinGen ExAC gnomAD
rs1046131062 CA20060290	7	T>A		No	ClinGen TOPMed
CA339541207 rs1216505248	7	T>I		No	ClinGen TOPMed
CA339541202 rs1326930027	8	V>F		No	ClinGen TOPMed gnomAD
CA20060284 rs1040836361	9	R>C		No	ClinGen TOPMed gnomAD
CA339541160 rs1040836361	9	R>G		No	ClinGen TOPMed gnomAD
CA728222 rs144278297	9	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728223 rs144278297	9	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1557471094 CA339541100	11	T>A		No	ClinGen Ensembl
CA339541074 rs1336914206	12	C>R		No	ClinGen gnomAD
rs1413556881 CA339540991	14	C>S		No	ClinGen gnomAD
rs746705065 CA728220	16	N>S		No	ClinGen ExAC TOPMed gnomAD
CA728218 rs373172801	18	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs188066738 CA728217	18	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373172801 CA728219	18	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA728215 rs369470045 COSM908109	20	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA728214 rs74977890	21	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728212 rs755216643	23	A>T	Variant assessed as Somatic; 4.733e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA728211 rs147094889	26	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1368013488 CA339540677	27	Y>F		No	ClinGen TOPMed
rs766751707 CA728210	28	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1307465026 CA339538358	31	M>I		No	ClinGen TOPMed
CA728174 rs768788733	31	M>L		No	ClinGen ExAC gnomAD
rs1407141940 CA339538366	31	M>T		No	ClinGen gnomAD
TCGA novel	32	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339538334 rs747071350	32	S>R		No	ClinGen ExAC TOPMed gnomAD
rs780272057 CA728169	33	V>I		No	ClinGen ExAC TOPMed gnomAD
CA728167 rs371661575	34	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1293939048 CA339538118	37	I>V		No	ClinGen TOPMed
rs772561163 CA728163	38	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1267801217 CA339538091	39	H>P		No	ClinGen gnomAD
rs755574951 CA728162	39	H>Y		No	ClinGen ExAC gnomAD
rs752182650 CA728161	40	S>L		No	ClinGen ExAC TOPMed gnomAD
CA339538080 rs1230957913	41	V>A		No	ClinGen TOPMed gnomAD
rs759085137 CA728159	41	V>I		No	ClinGen ExAC TOPMed gnomAD
CA339538056 rs1452863819	44	A>T		No	ClinGen TOPMed
rs751279906 CA728158	44	A>V		No	ClinGen ExAC gnomAD
rs1265835751 CA339538048	45	H>D		No	ClinGen TOPMed gnomAD
CA728157 rs766268584	48	A>S		No	ClinGen ExAC gnomAD
rs766268584 CA339538004	48	A>T		No	ClinGen ExAC gnomAD
rs762845113 CA728156	48	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA339537976 rs1217926837	50	C>R		No	ClinGen gnomAD
rs1364668987 CA339537894 CA339537892	55	M>I		No	ClinGen gnomAD
CA728154 rs769873607	58	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1386616033 CA339537806	61	A>T		No	ClinGen gnomAD
CA339537489 rs1201274300	64	I>V		No	ClinGen gnomAD
rs1352054810 CA339537479	65	S>A		No	ClinGen gnomAD
CA728118 rs144849255	66	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA339537352 rs1268029326	70	I>S		No	ClinGen TOPMed gnomAD
rs746540217 CA728117	70	I>V		No	ClinGen ExAC gnomAD
CA339537259 rs1458619741	72	M>T		No	ClinGen TOPMed
rs758091551 CA728115	75	I>F		No	ClinGen ExAC gnomAD
CA20050478 rs956358136	76	I>N		No	ClinGen Ensembl
rs1389190178 CA339537141	77	S>T		No	ClinGen TOPMed
CA339537107 rs1181877780	79	S>N		No	ClinGen gnomAD
rs1210975246 CA339537053	83	G>A		No	ClinGen gnomAD
CA728110 rs764117825	83	G>C		No	ClinGen ExAC gnomAD
rs1210975246 CA339537050	83	G>D		No	ClinGen gnomAD
CA339537055 rs764117825	83	G>S		No	ClinGen ExAC gnomAD
rs777435891 CA728106	84	V>A		No	ClinGen ExAC TOPMed gnomAD
CA728107 rs183822203 COSM908107	84	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1436630470 CA339536367	87	N>D		No	ClinGen TOPMed gnomAD
rs547749928 CA339536353	88	R>L		No	ClinGen ExAC TOPMed gnomAD
CA728085 COSM1256320 rs547749928	88	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA728086 rs765518717	88	R>W		No	ClinGen ExAC TOPMed gnomAD
CA339536316 rs1569857936	91	Y>S		No	ClinGen Ensembl
CA20049031 rs946606797	93	L>M		No	ClinGen Ensembl
CA20049030 rs893753079	93	L>R		No	ClinGen Ensembl
rs768949774 CA728083	95	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1247492999 CA339536263	97	S>T		No	ClinGen gnomAD
CA728081 rs776147713	99	Q>K		No	ClinGen ExAC gnomAD
rs778393608 CA728078	105	L>M		No	ClinGen ExAC gnomAD
CA339536200 rs1301088136	106	C>Y		No	ClinGen TOPMed gnomAD
rs35787459 CA20048947	107	L>M		No	ClinGen Ensembl
CA728076 rs748945466	108	L>F		No	ClinGen ExAC gnomAD
CA339536191 rs748945466	108	L>I		No	ClinGen ExAC gnomAD
rs1569857810 CA339536186	109	T>P		No	ClinGen Ensembl
rs534967531 CA20048941	112	G>A		No	ClinGen 1000Genomes
rs534967531 CA20048936	112	G>D		No	ClinGen 1000Genomes
CA728074 rs557747360	112	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA728072 rs781116816	113	S>F		No	ClinGen ExAC gnomAD
rs752561925 CA728073	113	S>P		No	ClinGen ExAC gnomAD
CA728071 rs758422746	114	Y>N		No	ClinGen ExAC gnomAD
rs750546368 CA339536155	115	I>L		No	ClinGen ExAC TOPMed gnomAD
rs765271074 CA728069	115	I>T		No	ClinGen ExAC TOPMed gnomAD
rs750546368 CA728070	115	I>V		No	ClinGen ExAC TOPMed gnomAD
CA728068 rs762072505	116	E>K		No	ClinGen ExAC gnomAD
rs754076563 CA728067	118	P>S		No	ClinGen ExAC gnomAD
CA728064 rs139678458	119	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs145636949 CA728063	119	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728061 rs773891848	121	L>H		No	ClinGen ExAC TOPMed gnomAD
CA339536113 rs1445544515	122	K>R		No	ClinGen TOPMed
CA339536114 rs1445544515	122	K>T		No	ClinGen TOPMed
rs770409083 CA728060	123	L>S		No	ClinGen ExAC gnomAD
CA339536091 rs549310638	126	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs141499795 CA728058	126	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728059 rs549310638	126	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA728057 rs769516896	127	S>G		No	ClinGen ExAC gnomAD
CA339536083 rs1284382849	127	S>R		No	ClinGen TOPMed
rs747955844 CA728056	128	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781067463 CA728055	128	R>H		No	ClinGen ExAC TOPMed gnomAD
CA339536037 rs1481835714	133	K>M		No	ClinGen gnomAD
TCGA novel	134	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339536022 rs1359535138	135	P>L		No	ClinGen gnomAD
CA728029 rs34101571	135	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1392006173 CA339536010	137	M>I		No	ClinGen gnomAD
CA728027 rs200810512	138	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	140	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1253423170 CA339535990	140	Q>L		No	ClinGen TOPMed
rs1183249235 CA339535977	143	D>N		No	ClinGen gnomAD
CA20048244 rs370272502	144	F>C		No	ClinGen ESP TOPMed gnomAD
TCGA novel	147	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1227748785 CA339535924	150	T>I		No	ClinGen gnomAD
TCGA novel	152	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1350113042 CA339535903	153	S>I		No	ClinGen TOPMed
CA20048235 rs756171596	153	S>R		No	ClinGen Ensembl
rs1350113042 CA339535904	153	S>T		No	ClinGen TOPMed
rs867345460 CA20048218	154	S>F		No	ClinGen Ensembl
rs1224748061 CA339535896	155	Y>H		No	ClinGen TOPMed
rs1379569040 CA339535884	156	M>T		No	ClinGen gnomAD
CA339535887 rs1396859658	156	M>V		No	ClinGen gnomAD
TCGA novel	157	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA728023 rs752782257	158	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1327856381 CA339535864	159	P>S		No	ClinGen TOPMed
CA339535853 rs1372327761	161	Y>H		No	ClinGen gnomAD
TCGA novel	164	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339535813 COSM534681 rs1460990190	166	S>F	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1389311570 CA339535807	167	M>T		No	ClinGen TOPMed
CA728022 rs764774321	167	M>V		No	ClinGen ExAC gnomAD
rs1298507257 CA339535793	169	H>D		No	ClinGen TOPMed
CA339535514 rs1381551671	172	Y>H		No	ClinGen gnomAD
rs1569854737 CA339535511	172	Y>S		No	ClinGen Ensembl
rs1392868891 CA339535492	174	P>S		No	ClinGen gnomAD
rs1396965217 CA339535478	175	S>G		No	ClinGen gnomAD
rs1355357152 CA339535463	176	Q>R		No	ClinGen TOPMed
CA20047292 rs369299830	177	E>K		No	ClinGen ESP TOPMed
CA20047284 rs866914981	178	D>N		No	ClinGen Ensembl
CA339535428 rs1468140474	179	M>I		No	ClinGen gnomAD
CA20047276 rs200376170	179	M>R		No	ClinGen gnomAD
CA339535430 rs200376170	179	M>T		No	ClinGen gnomAD
CA339535433 rs1244901743	179	M>V		No	ClinGen TOPMed
rs372654193 CA728007	180	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs375995678 CA728008	180	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs758807421 CA728006	182	N>K		No	ClinGen ExAC gnomAD
COSM185204 CA728005 rs772801469	187	M>I	upper_aerodigestive_tract large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA728004 rs764721370	190	I>L		No	ClinGen ExAC TOPMed gnomAD
CA339535263 rs1333875769	192	S>F		No	ClinGen gnomAD
rs993589876 CA20047200	194	A>T		No	ClinGen TOPMed gnomAD
rs1323432579 CA339535228	195	F>S		No	ClinGen gnomAD
rs546482766 CA20047194	196	I>F		No	ClinGen 1000Genomes gnomAD
rs1412064516 CA339535162	199	L>R		No	ClinGen TOPMed
CA728002 rs776216936	200	I>T		No	ClinGen ExAC TOPMed gnomAD
rs11541206 CA728000	202	K>N		No	ClinGen ExAC gnomAD
rs763687921 CA728001	202	K>T		No	ClinGen ExAC
rs764594879 CA727977	205	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1339499019 CA339556018	208	C>G		No	ClinGen gnomAD
CA339556017 rs1269159729	208	C>Y		No	ClinGen gnomAD
CA339556010 rs1342583320	209	V>L		No	ClinGen TOPMed gnomAD
rs1342583320 CA339556012	209	V>M		No	ClinGen TOPMed gnomAD
rs138163595 CA727974	211	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1335245110 CA339555996	211	R>W		No	ClinGen gnomAD
rs772379976 CA727972	213	Y>C		No	ClinGen ExAC gnomAD
CA339555971 rs746263342	215	L>V		No	ClinGen ExAC TOPMed gnomAD
CA727970 rs374608139	219	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA339555940 COSM1687313 rs1418897920	219	M>V	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs761225896 CA727969	221	S>L		No	ClinGen ExAC gnomAD
CA727966 rs755659020	222	V>A		No	ClinGen ExAC gnomAD
rs370275111 CA727967	222	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA20104334 rs987344783	223	E>K		No	ClinGen TOPMed gnomAD
rs1207221287 CA339555909	224	E>K		No	ClinGen gnomAD
rs35351292 VAR_053653 CA727964	226	R>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA20104331 rs35351292	226	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1569852087 CA339555884	227	N>T		No	ClinGen Ensembl
rs1293600918 CA339555878	228	S>A		No	ClinGen gnomAD
CA727962 rs759360466	229	K>Q		No	ClinGen ExAC gnomAD
rs766323570 CA727960	230	M>I		No	ClinGen ExAC gnomAD
rs751366621 CA727961	230	M>V		No	ClinGen ExAC gnomAD
rs762969146 CA727959	231	L>F		No	ClinGen ExAC gnomAD
rs773264858 CA727958	232	Q>H		No	ClinGen ExAC gnomAD
rs1269701689 CA339555286	236	L>P		No	ClinGen gnomAD
CA727935 rs147666160	237	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA339555283 rs767643820	237	P>S		No	ClinGen ExAC TOPMed gnomAD
CA727936 rs767643820	237	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1221466956 CA339555274	238	S>A		No	ClinGen gnomAD
CA20103059 rs932823511	238	S>Y		No	ClinGen Ensembl
rs1429888789 CA339555255	239	Y>C		No	ClinGen TOPMed
rs145384305 COSM426057 CA727931	240	E>K	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA727930 COSM3943861 rs770301183	241	E>G	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1289725853 CA339555207	242	A>G		No	ClinGen gnomAD
CA20103046 rs779644407	242	A>T		No	ClinGen Ensembl
rs781309185 CA727929	247	S>A		No	ClinGen ExAC TOPMed gnomAD
rs780833255 CA727928	247	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781309185 CA20103039	247	S>T		No	ClinGen ExAC TOPMed gnomAD
rs113336710 CA727927	249	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339555105 rs1452092284	250	P>A		No	ClinGen gnomAD
CA727926 rs746591610	250	P>R		No	ClinGen ExAC gnomAD
CA339555066 rs1021393675	251	E>D		No	ClinGen TOPMed
CA727925 rs779865690	252	G>W		No	ClinGen ExAC TOPMed gnomAD
CA339555044 rs1240744096	253	G>D		No	ClinGen gnomAD
TCGA novel	254	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1280318604 CA339555022	255	A>P		No	ClinGen gnomAD
rs1280318604 CA339555025	255	A>T		No	ClinGen gnomAD
CA20103000 rs374167496	255	A>V		No	ClinGen ESP TOPMed gnomAD
rs750201690 CA727923	257	P>L		No	ClinGen ExAC TOPMed gnomAD
CA339554997 rs1344424614	257	P>S		No	ClinGen TOPMed gnomAD
rs1344424614 CA339555000	257	P>T		No	ClinGen TOPMed gnomAD
rs768410389 CA727922	258	P>A		No	ClinGen ExAC TOPMed gnomAD
CA20102967 rs371021746	259	Y>N		No	ClinGen ESP TOPMed
rs767520995 CA727919	262	V>M		No	ClinGen ExAC TOPMed gnomAD
CA339554851 rs535029927	263	V>C		No	ClinGen 1000Genomes ExAC gnomAD
CA727918 rs535029927	263	V>W		No	ClinGen 1000Genomes ExAC gnomAD

No associated diseases with Q13571

No regional properties for Q13571

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q13571

Functions

		Description
EC Number
Subcellular Localization	Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
transport vesicle	Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

3 GO annotations of molecular function

Name	Definition
protein sequestering activity	Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin-dependent protein binding	Binding to a protein upon ubiquitination of the target protein.

22 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
defense response to tumor cell	Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
Golgi to lysosome transport	The directed movement of substances from the Golgi to lysosomes.
induction of programmed cell death	A process which directly activates any of the steps required for programmed cell death.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
negative regulation of autophagic cell death	Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.
negative regulation of B cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
negative regulation of interferon-gamma production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
negative regulation of interleukin-2 production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
negative regulation of T cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
negative regulation of T cell receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
positive regulation of cytokine production involved in immune response	Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
positive regulation of interleukin-12 production	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of lysosomal membrane permeability	Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.
positive regulation of macrophage cytokine production	Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of NIK/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of protein ubiquitination	Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
positive regulation of receptor catabolic process	Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
positive regulation of tumor necrosis factor-mediated signaling pathway	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.
positive regulation of ubiquitin-dependent protein catabolic process	Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
protein targeting to lysosome	The process of directing proteins towards the lysosome using signals contained within the protein.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KJA5	LAPTM5	Lysosomal-associated transmembrane protein 5	Bos taurus (Bovine)	PR
Q61168	Laptm5	Lysosomal-associated transmembrane protein 5	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MDPRLSTVRQ	TCCCFNVRIA	TTALAIYHVI	MSVLLFIEHS	VEVAHGKASC	KLSQMGYLRI
70	80	90	100	110	120
ADLISSFLLI	TMLFIISLSL	LIGVVKNREK	YLLPFLSLQI	MDYLLCLLTL	LGSYIELPAY
130	140	150	160	170	180
LKLASRSRAS	SSKFPLMTLQ	LLDFCLSILT	LCSSYMEVPT	YLNFKSMNHM	NYLPSQEDMP
190	200	210	220	230	240
HNQFIKMMII	FSIAFITVLI	FKVYMFKCVW	RCYRLIKCMN	SVEEKRNSKM	LQKVVLPSYE
250	260
EALSLPSKTP	EGGPAPPPYS	EV