AiPD: Autoinhibited Protein Database

Gene name	Tnfrsf8
Protein name	Tumor necrosis factor receptor superfamily member 8
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:21941
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

172-269 (Predicted disordered autoinhibitory region) PR

172-269 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q60846-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3395109828	15	M>I	No	EVA
rs3395198202	15	M>L	No	EVA
rs3395034817	17	Q>E	No	EVA
rs3395109795	19	F>S	No	EVA
rs3388724519	29	C>R	No	EVA
rs232523619	39	E>G	No	EVA
rs3388729235	43	N>Y	No	EVA
rs256456359	44	C>Y	No	EVA
rs3388717682	49	P>T	No	EVA
rs214131264	60	R>Q	No	EVA
rs254206046	61	G>D	No	EVA
rs3388728200	111	M>V	No	EVA
rs3388730898	120	S>P	No	EVA
rs3388706338	121	C>R	No	EVA
rs231731004	132	E>K	No	EVA
rs3388726164	154	G>S	No	EVA
rs27627526	161	G>D	No	EVA
rs27627527	167	T>I	No	EVA
rs27627530	173	Q>R	No	EVA
rs27627531	187	R>K	No	EVA
rs3388726129	188	S>N	No	EVA
rs3394892652	198	V>L	No	EVA
rs3388730956	205	L>S	No	EVA
rs3388718839	214	S>F	No	EVA
rs27627533	219	P>S	No	EVA
rs3388731231	232	L>M	No	EVA
rs251339993	251	E>D	No	EVA
rs3388735450	263	V>E	No	EVA
rs221962591	296	V>A	No	EVA
rs3388735435	326	L>P	No	EVA
rs218564153	337	T>A	No	EVA
rs3388722660	350	R>I	No	EVA
rs265478761	352	G>R	No	EVA
rs225702082	359	T>A	No	EVA
rs3388718892	359	T>M	No	EVA
rs3388731226	363	L>M	No	EVA
rs258492786	364	S>N	No	EVA
rs236817976	366	V>A	No	EVA
rs3388731437	397	P>L	No	EVA
rs3388724503	418	E>K	No	EVA
rs3388730936	425	A>P	No	EVA
rs1134377582	441	R>Q	No	EVA
rs3394765264	464	P>PPRT*	No	EVA
rs3388735496	465	E>K	No	EVA

Type	Name	Position	InterPro Accession
domain	TNFR/NGFR cysteine-rich region	29 - 65	IPR001368-1
domain	TNFR/NGFR cysteine-rich region	68 - 105	IPR001368-2
domain	TNFR/NGFR cysteine-rich region	106 - 146	IPR001368-3
domain	Tumour necrosis factor receptor 8, N-terminal	3 - 127	IPR034002

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
transmembrane signaling receptor activity	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

Name	Definition
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of TRAIL production	Any process that activates or increases the frequency, rate, or extent of TRAIL production.
positive regulation of tumor necrosis factor production	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P97525	Tnfrsf8	Tumor necrosis factor receptor superfamily member 8	Rattus norvegicus (Rat)	PR