P97525

PR
Gene name
Tnfrsf8
Protein name
Tumor necrosis factor receptor superfamily member 8
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25069
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

167-293 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97525

Entry ID Method Resolution Chain Position Source
AF-P97525-F1 Predicted AlphaFoldDB

No variants for P97525

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P97525

No associated diseases with P97525

2 regional properties for P97525

Type Name Position InterPro Accession
domain TNFR/NGFR cysteine-rich region 29 - 104 IPR001368-1
domain TNFR/NGFR cysteine-rich region 106 - 141 IPR001368-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

6 GO annotations of biological process

Name Definition
cellular response to mechanical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of TRAIL production Any process that activates or increases the frequency, rate, or extent of TRAIL production.
positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q60846 Tnfrsf8 Tumor necrosis factor receptor superfamily member 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSILLKAAGL LFLGMLQAFP KDRPLDTTCT GDLSYYPGEA ARNCCYQCPS GLSPTQPCPQ
70 80 90 100 110 120
GPATARSSVI LTTTNEDRKC TACVTCLPGL VEKAPCSGNS PRICECQPGM YCSTPAVNSC
130 140 150 160 170 180
ARCSEKTVVK FPDTAEKNTI CDLPSPGSGP NGSNPDDCKT LTSHTTPQAI PTLESPANDS
190 200 210 220 230 240
VRSLLPKQVT DFVNEGATKL VKVPESSSSK ASMPSPDPGN AEMNMTLKLP PPGTVPDIST
250 260 270 280 290 300
SENSMEPAST ASTLSLLVDA RTSSRMQPTS PLSTGTPFLD PGSMLFWVAM VVLLVGSASF
310 320 330 340 350 360
LLCYWKACRR RFQRKFHLNY LQQTFQPKME QVDSCPTEKL TQLQRSGSVT DSSAGHTLSP
370 380 390 400 410 420
LSPPAVETGA SVGTACLETL PLLDDSITGN SFAPREPPEP RVSTEHTNNR IEKIYIMKAD
430 440 450 460 470 480
TVIVGSVKTE VPEGRAPVGS TESELEAELE VDHTPHYPEQ ETEPPLGSCT EVMFSVEEGG
490
KEDHEPTTVS EK