Q5ZME8
Gene name |
SMU1 (RCJMB04_2e22) |
Protein name |
WD40 repeat-containing protein SMU1 |
Names |
Smu-1 suppressor of mec-8 and unc-52 protein homolog |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:427377 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZME8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZME8-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZME8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZME8 | |||||
No associated diseases with Q5ZME8
1 regional properties for Q5ZME8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NUC153 | 753 - 781 | IPR012580 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| regulation of alternative mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBS9 | SMU1 | WD40 repeat-containing protein SMU1 | Bos taurus (Bovine) | PR |
| Q2TAY7 | SMU1 | WD40 repeat-containing protein SMU1 | Homo sapiens (Human) | PR |
| Q3UKJ7 | Smu1 | WD40 repeat-containing protein SMU1 | Mus musculus (Mouse) | PR |
| Q99M63 | Smu1 | WD40 repeat-containing protein SMU1 | Rattus norvegicus (Rat) | PR |
| Q8W117 | SMU1 | Suppressor of mec-8 and unc-52 protein homolog 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7ZVA0 | smu1 | WD40 repeat-containing protein SMU1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIEIESSDV | IRLIMQYLKE | NSLHRALATL | QEETTVSLNT | VDSIESFVAD | INSGHWDTVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QAIQSLKLPD | KTLIDLYEQV | VLELIELREL | GAARSLLRQT | DPMIMLKQTQ | PERYIHLENL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LARSYFDPRE | AYPDGSSKEK | RRAAIAQALA | GEVSVVPPSR | LMALLGQALK | WQQHQGLLPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GMTIDLFRGK | AAVKDVEEEK | FPTQLSRHIK | FGQKSHVECA | RFSPDGQYLV | TGSVDGFIEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WNFTTGKIRK | DLKYQAQDNF | MMMDDAVLCM | CFSRDTEMLA | TGAQDGKIKV | WKIQSGQCLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RFERAHSKGV | TCLSFSKDSS | QILSASFDQT | IRIHGLKSGK | TLKEFRGHSS | FVNEATFTQD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GHYIISASSD | GTVKVWNVKT | TECSNTFKSL | GSTAGTDITV | NSVILLPKNP | EHFVVCNRSN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVVIMNMQGQ | IVRSFSSGKR | EGGDFVCCAL | SPRGEWIYCV | GEDFVLYCFS | TVTGKLERTL |
| 490 | 500 | 510 | |||
| TVHEKDVIGI | AHHPHQNLIA | TYSEDGLLKL | WKP |