Q5ZLK1

PR
Gene name
DCAF13 (WDSOF1, RCJMB04_5m12)
Protein name
DDB1- and CUL4-associated factor 13
Names
WD repeat and SOF domain-containing protein 1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:420263
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

380-445 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZLK1

Entry ID Method Resolution Chain Position Source
AF-Q5ZLK1-F1 Predicted AlphaFoldDB

No variants for Q5ZLK1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZLK1

No associated diseases with Q5ZLK1

5 regional properties for Q5ZLK1

Type Name Position InterPro Accession
repeat WD40 repeat 55 - 137 IPR001680-1
repeat WD40 repeat 185 - 225 IPR001680-2
repeat WD40 repeat 271 - 362 IPR001680-3
domain Sof1-like protein 354 - 440 IPR007287
conserved_site WD40 repeat, conserved site 82 - 96 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P33750 SOF1 Protein SOF1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9NV06 DCAF13 DDB1- and CUL4-associated factor 13 Homo sapiens (Human) PR
10 20 30 40 50 60
MRVKVLSRNP DDYVRETKLD LQRVPRNYDP ALHPFEVARE YVRALNATKL ERVFAKPFLS
70 80 90 100 110 120
SLDGHRDGVN CMAKHPKSLS TVLSGACDGE VRIWNLTKRQ CIRALQAHEG FVRGMCARFC
130 140 150 160 170 180
GTSFFTVGDD KTVKQWKMES PGYGEEEEPI HTILGKTVYT GIDHHWKDAV FATCGQQVDI
190 200 210 220 230 240
WDEQRTSPMC SLTWGFDSIS SVKFNPIETY LLGSCASDRN IVLYDMRQST PLKKVILNMR
250 260 270 280 290 300
TNTLCWNPME AFIFTAANED YNLYTFDMRF LTSPVMVHMD HVSAVLDVDY SPTGKEFVSA
310 320 330 340 350 360
SFDKSVRIFP VDKGHSREVY HTKRMQHVIT VKWTSDSRYI LCGSDEMNIR LWKANASEKL
370 380 390 400 410 420
GVLAPREKAA MNYNQKLKEK FQHHPQIKRI ARHRHLPKSI YCQIKEQRIM REARRRKELN
430 440
RRKHSKPGSV PVVSEKKKHI VAVVQ