P33750

PR
Gene name
SOF1 (YLL011W, L1339)
Protein name
Protein SOF1
Names
U3 small nucleolar RNA-associated protein SOF1, U3 snoRNA-associated protein SOF1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLL011W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

22 structures for P33750

Entry ID Method Resolution Chain Position Source
5WLC EM 380 A LU 1-489 PDB
6KE6 EM 340 A 5I 1-489 PDB
6LQP EM 320 A 5I 1-489 PDB
6LQQ EM 410 A 5I 1-489 PDB
6LQR EM 860 A 5I 1-489 PDB
6LQS EM 380 A 5I 1-489 PDB
6LQT EM 490 A 5I 1-489 PDB
6LQU EM 370 A 5I 1-489 PDB
6LQV EM 480 A 5I 1-489 PDB
6ND4 EM 430 A U 1-489 PDB
6ZQA EM 440 A JP 1-489 PDB
6ZQB EM 390 A JP 1-489 PDB
6ZQC EM 380 A JP 1-489 PDB
6ZQD EM 380 A JP 1-489 PDB
7AJT EM 460 A JP 1-489 PDB
7AJU EM 380 A JP 1-489 PDB
7D4I EM 400 A 5I 1-489 PDB
7D5S EM 460 A 5I 1-489 PDB
7D5T EM 600 A 5I 1-489 PDB
7D63 EM 1230 A 5I 1-489 PDB
7SUK EM 399 A LU 1-465 PDB
AF-P33750-F1 Predicted AlphaFoldDB

6 variants for P33750

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-127921 134 N>D No SGRP
s12-127971 150 I>M No SGRP
s12-128099 193 T>M No SGRP
s12-128120 200 K>M No SGRP
s12-128715 398 E>D No SGRP
s12-128876 452 P>L No SGRP

No associated diseases with P33750

8 regional properties for P33750

Type Name Position InterPro Accession
repeat WD40 repeat 55 - 149 IPR001680-1
repeat WD40 repeat 169 - 205 IPR001680-2
repeat WD40 repeat 208 - 290 IPR001680-3
repeat WD40 repeat 294 - 376 IPR001680-4
domain Sof1-like protein 377 - 461 IPR007287
repeat G-protein beta WD-40 repeat 83 - 97 IPR020472-1
repeat G-protein beta WD-40 repeat 136 - 150 IPR020472-2
repeat G-protein beta WD-40 repeat 363 - 377 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

2 GO annotations of biological process

Name Definition
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLK1 DCAF13 DDB1- and CUL4-associated factor 13 Gallus gallus (Chicken) PR
Q9NV06 DCAF13 DDB1- and CUL4-associated factor 13 Homo sapiens (Human) PR
10 20 30 40 50 60
MKIKTIKRSA DDYVPVKSTQ ESQMPRNLNP ELHPFERARE YTKALNATKL ERMFAKPFVG
70 80 90 100 110 120
QLGYGHRDGV YAIAKNYGSL NKLATGSADG VIKYWNMSTR EEFVSFKAHY GLVTGLCVTQ
130 140 150 160 170 180
PRFHDKKPDL KSQNFMLSCS DDKTVKLWSI NVDDYSNKNS SDNDSVTNEE GLIRTFDGES
190 200 210 220 230 240
AFQGIDSHRE NSTFATGGAK IHLWDVNRLK PVSDLSWGAD NITSLKFNQN ETDILASTGS
250 260 270 280 290 300
DNSIVLYDLR TNSPTQKIVQ TMRTNAICWN PMEAFNFVTA NEDHNAYYYD MRNLSRSLNV
310 320 330 340 350 360
FKDHVSAVMD VDFSPTGDEI VTGSYDKSIR IYKTNHGHSR EIYHTKRMQH VFQVKYSMDS
370 380 390 400 410 420
KYIISGSDDG NVRLWRSKAW ERSNVKTTRE KNKLEYDEKL KERFRHMPEI KRISRHRHVP
430 440 450 460 470 480
QVIKKAQEIK NIELSSIKRR EANERRTRKD MPYISERKKQ IVGTVHKYED SGRDRKRRKE
DDKRDTQEK