Q5XI83

PR
Gene name
Vps35l
Protein name
VPS35 endosomal protein-sorting factor-like
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361635
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-195 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XI83

Entry ID Method Resolution Chain Position Source
AF-Q5XI83-F1 Predicted AlphaFoldDB

1 variants for Q5XI83

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3319120949 498 S>N No EVA

No associated diseases with Q5XI83

No regional properties for Q5XI83

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5XI83

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
  • Endosome
  • Endosome location is dependent of the association with the CCC and WASH complexes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z3J2 VPS35L VPS35 endosomal protein-sorting factor-like Homo sapiens (Human) PR
Q8BWQ6 Vps35l VPS35 endosomal protein-sorting factor-like Mus musculus (Mouse) PR
10 20 30 40 50 60
MAVFPWHSRN RNYKAELASC RLETVPLECG DYHPLKPITV TESKTKKVSR KGSTSSTSSS
70 80 90 100 110 120
SSSSVVDPLS SVLDGTDPLS MFAATSDPAA TVTVTESSRK KRDKDDNSFV GPDFEPWANK
130 140 150 160 170 180
RGEILARYTT TEKLSINLFM GSEKGRAGAA ASAMSEKVRT RLEELDDFEE GSQKELLNLT
190 200 210 220 230 240
QQDYVNRIEE LNQSLKDAWA SDQKVKALKI VIQCSKLLSD TSVIQFYPSK FVLITDILDT
250 260 270 280 290 300
FGKLVYERIY SMCVDSRGAL PDHFSPENVN DTAKETCLNW FFKIASIREL IPRFYVEASI
310 320 330 340 350 360
LKCNKFLSKT GISECLPRLT CMIRGIGDPL VSVYARAYLC RVGMEVAPHL KESLTRNFFD
370 380 390 400 410 420
FLLTFKQIHG DTVQNQLVAQ GVELLSYLPL YSPAMGWIFQ CVSYHAPEAL LTEMMERCKK
430 440 450 460 470 480
LGNNALLLNS VMSAFRAEFI ATRSMDFIGM IKECDESGFP KHLLFRSLGV NLALADPPEN
490 500 510 520 530 540
DRLQILNEAW KVITKLKSPQ DYINCAEVWV EYTCRHFTKR EVNTVLADVI KHMTPDRAFE
550 560 570 580 590 600
DSYPQLQSII KKVIAHFHDF SVLFSVEKFL PFLDMFQKES VRVEVCKCIM EAFINALTLE
610 620 630 640 650 660
DEKRMLAHLI NGFIKMVSFG RDFEQQLSFY VESRSMFCNL EPVLVQLIHS VNRLAMETRK
670 680 690 700 710 720
VMKGNHSRKT AAFVRACVAY CFITIPSLVG IFTRLNLYLH SGQVALANQC LSQADAFFKA
730 740 750 760 770 780
AISLVPEVPK SISIDGKLRP SEPFLLEFLC NFFSTLLIVP DHPEHGVLFL VRELLNVIQD
790 800 810 820 830 840
YTWEDSSDDK IRIYTSVLHL LSAMSQDTYL YHIDKVDSND SLYGGDSRFL AENSKLCEAA
850 860 870 880 890 900
MVQILEHLKT LAKDEALKRQ SLLGLSFFNS ILAHGDLRNN KLNQLSVNLW HLAQRHGCAD
910 920 930
TRTMVKTLDY IKKRSKQPDM NHLSELALRL PLQTRT