Q5U2R3

PR
Gene name
Frmd8
Protein name
FERM domain-containing protein 8
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:309172
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U2R3

Entry ID Method Resolution Chain Position Source
AF-Q5U2R3-F1 Predicted AlphaFoldDB

No variants for Q5U2R3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U2R3

No associated diseases with Q5U2R3

3 regional properties for Q5U2R3

Type Name Position InterPro Accession
domain FERM domain 30 - 377 IPR000299
domain FERM central domain 136 - 273 IPR019748
domain Band 4.1 domain 26 - 273 IPR019749

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
centriolar satellite A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BZ67 FRMD8 FERM domain-containing protein 8 Homo sapiens (Human) PR
Q3UFK8 Frmd8 FERM domain-containing protein 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEGAEGNAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLS SISAHELHRA
70 80 90 100 110 120
VREVLQLPDM ALEAFALWLV SPLLEVQLKP KHQPYKLGRQ WPELLLRFTD ASDDDIAMDE
130 140 150 160 170 180
PSLQFRRNVF FPKRRELQVH DEEVLRLLYE EAKGNVLTAR YPCDLEDCEV LGGLVCRVQL
190 200 210 220 230 240
GPYQPGQPAA CTVREKLDSF LPAHLCKRGH GLFAAFRGRG AKTGPCEQGL LNAYRQVKEM
250 260 270 280 290 300
AGGDSERETT LGSHYRAYLL KCHELPFYGC AFFHGEVDKP TQGFLHRGGR KPVTVAISLE
310 320 330 340 350 360
GVHVIDNREK HVLLGLRFQE LSWDHTSPEE EEPVLWLEFD GDSEGTPVNK LLRIYSKQAE
370 380 390 400 410 420
LMSVLIEYCI ELSQAAEPAL PQESASGPQE APSPSSAPTQ RPKLRRQGSV VCSRIQHLST
430 440 450 460
IDYVEDGSGI KRVKPKRTTS FFSRQLSSSH GSYTVVQPND NSPEQG