AiPD: Autoinhibited Protein Database

Gene name	Frmd8
Protein name	FERM domain-containing protein 8
Names	iRhom tail-associated protein, iTAP
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:67457
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-53 (Predicted disordered autoinhibitory region) PR

1-53 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3UFK8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389528989	2	E>*	No	EVA
rs3389523895	8	A>T	No	EVA
rs260501612	14	A>V	No	EVA
rs3389468311	21	S>G	No	EVA
rs3389521015	21	S>T	No	EVA
rs3389518875	25	V>M	No	EVA
rs3389519932	82	P>L	No	EVA
rs3389476795	100	Q>H	No	EVA
rs13461043	110	N>D	No	EVA
rs3389468216	119	D>E	No	EVA
rs3389523902	139	I>F	No	EVA
rs36312787	140	H>L	No	EVA
rs3389512048	148	L>I	No	EVA
rs3408970507	164	D>N	No	EVA
rs3389514713	180	L>I	No	EVA
rs3389468300	184	Q>R	No	EVA
rs3389519902	188	P>H	No	EVA
rs215476575	190	A>T	No	EVA
rs249040022	191	C>Y	No	EVA
rs36559106	218	G>S	No	EVA
rs228559653	244	N>D	No	EVA
rs38253571	304	V>I	No	EVA
rs3389476825	306	D>Y	No	EVA
rs3409005362	322	S>*	No	EVA
rs3389514704	343	S>N	No	EVA
rs3389535281	346	T>M	No	EVA
rs3408902890	349	N>T	No	EVA
rs3406972398	350	K>N	No	EVA
rs235883886	376	A>S	No	EVA
rs3389429104	436	K>M	No	EVA
rs3389429108	438	T>P	No	EVA
rs3389514695	445	Q>H	No	EVA
rs3389512895	449	S>N	No	EVA

Type	Name	Position	InterPro Accession
domain	FERM domain	30 - 377	IPR000299
domain	FERM central domain	136 - 273	IPR019748
domain	Band 4.1 domain	26 - 273	IPR019749

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
centriolar satellite	A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
No GO annotations for molecular function

Name	Definition
negative regulation of canonical Wnt signaling pathway	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of tumor necrosis factor production	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BZ67	FRMD8	FERM domain-containing protein 8	Homo sapiens (Human)	PR
Q5U2R3	Frmd8	FERM domain-containing protein 8	Rattus norvegicus (Rat)	PR