Q5TYV0

PR
Gene name
emc7 (si:ch211-150c22.3)
Protein name
ER membrane protein complex subunit 7
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:561549
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

175-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5TYV0

Entry ID Method Resolution Chain Position Source
AF-Q5TYV0-F1 Predicted AlphaFoldDB

No variants for Q5TYV0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5TYV0

No associated diseases with Q5TYV0

4 regional properties for Q5TYV0

Type Name Position InterPro Accession
domain RNA recognition motif domain 58 - 129 IPR000504-1
domain RNA recognition motif domain 131 - 209 IPR000504-2
domain RNA recognition motif domain 220 - 298 IPR000504-3
domain Ribonucleoprotein PTB-binding 2, RNA recognition motif 2 132 - 208 IPR034636

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

2 GO annotations of biological process

Name Definition
protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJA8 EMC7 ER membrane protein complex subunit 7 Bos taurus (Bovine) PR
Q9NPA0 EMC7 ER membrane protein complex subunit 7 Homo sapiens (Human) PR
Q9EP72 Emc7 ER membrane protein complex subunit 7 Mus musculus (Mouse) PR
Q0IHY5 emc7 ER membrane protein complex subunit 7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MPHIKRLLDV YIALQALFAL SWGFSDPEPG PVAASQSNGD RFKIEGRAIV PGVKTQDWIS
70 80 90 100 110 120
TARVLVEGEE YVGFLKTDGS FAVNDVPSGS YVVEIVSPSF RFEPVRVDIT SKGKMRARLV
130 140 150 160 170 180
NYIKTSEVIR QPYPLQIRAG GPHTYFMKRE TWGWTDFLMN PMVMMMVLPL LIIVLLPKVV
190 200 210 220 230
NTNDPEMRKE MEQSMNMLNP NPELPDVSEF MTKLFSKGSS KSGGGNKGSR SVATKRR