Q0IHY5

PR
Gene name
emc7
Protein name
ER membrane protein complex subunit 7
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:780022
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0IHY5

Entry ID Method Resolution Chain Position Source
AF-Q0IHY5-F1 Predicted AlphaFoldDB

No variants for Q0IHY5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0IHY5

No associated diseases with Q0IHY5

7 regional properties for Q0IHY5

Type Name Position InterPro Accession
domain FERM domain 17 - 298 IPR000299
domain FERM adjacent 308 - 354 IPR014847
domain FERM, N-terminal 21 - 83 IPR018979
domain FERM, C-terminal PH-like domain 214 - 302 IPR018980
conserved_site FERM conserved site 71 - 100 IPR019747
domain FERM central domain 103 - 210 IPR019748
domain Band 4.1 domain 13 - 210 IPR019749

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJA8 EMC7 ER membrane protein complex subunit 7 Bos taurus (Bovine) PR
Q9NPA0 EMC7 ER membrane protein complex subunit 7 Homo sapiens (Human) PR
Q9EP72 Emc7 ER membrane protein complex subunit 7 Mus musculus (Mouse) PR
Q5TYV0 emc7 ER membrane protein complex subunit 7 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPAVALGVSV GWRSLSLWLL ALLQLCSADL DVLSPGSGSD KFKVEGRAVV PGVRPQDWVN
70 80 90 100 110 120
TARVLVDGEE HVGFLRTDGS FVVHDVPSGS YVVEVISPAH RFEPVRVDIT SKGKMRARYV
130 140 150 160 170 180
NHIKTSEVVR LPYPLQMKSS GPPSYFIKRE TWGWTDFLMN PMVMMMVLPL LIFVLLPKVV
190 200 210 220 230
NTSDPEMRRE MEQSMNMLNT NPELPDVSEF MTRLFTSKSS SKSSGSGKAG KSVGKRR