Q5TM19

PR
Gene name
NFKBIL1
Protein name
NF-kappa-B inhibitor-like protein 1
Names
Inhibitor of kappa B-like protein, I-kappa-B-like protein, IkappaBL, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Species
Macaca mulatta (Rhesus macaque)
KEGG Pathway
mcc:715283
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-300 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5TM19

Entry ID Method Resolution Chain Position Source
AF-Q5TM19-F1 Predicted AlphaFoldDB

No variants for Q5TM19

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5TM19

No associated diseases with Q5TM19

1 regional properties for Q5TM19

Type Name Position InterPro Accession
repeat Ankyrin repeat 67 - 109 IPR002110

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nuclear localization with a speckled expression pattern in some cells
  • Colocalizes with CACTIN in the nucleus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
I-kappaB kinase/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
negative regulation of lipopolysaccharide-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
negative regulation of NF-kappaB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
negative regulation of toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
negative regulation of tumor necrosis factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UBC1 NFKBIL1 NF-kappa-B inhibitor-like protein 1 Homo sapiens (Human) PR
O88995 Nfkbil1 NF-kappa-B inhibitor-like protein 1 Mus musculus (Mouse) PR
Q9TSV7 NFKBIL1 NF-kappa-B inhibitor-like protein 1 Sus scrofa (Pig) PR
10 20 30 40 50 60
MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ ALLQRHPGLD
70 80 90 100 110 120
VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT ALHAAARQGP DAYTDFFLPL
130 140 150 160 170 180
LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS AEEEEEDDAS KEREWRQKLQ GELEDEWQEV
190 200 210 220 230 240
MGRFEGDASH ETQEPESFSA WSDRLAREHA QKCQQQQREA EGSCRPPRAE GSSQSWRQQE
250 260 270 280 290 300
EEQRLFRERA RVKEEELRES RARRAQEALG DREPKPARAG PRAEHPRGAG RGSLWRFGDV
310 320 330 340 350 360
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL RRYLRVQQVR WHPDRFLQRF RSQIETWELG
370 380
RVMGAVTALS QALNRHAEAL K