AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

513-677 (Predicted disordered autoinhibitory region) PR

513-677 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5SWY7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3402080624	2	A>P	No	EVA
rs3401713613	3	F>L	No	EVA
rs3389166262	11	D>V	No	EVA
rs3389102727	29	E>K	No	EVA
rs3389128659	34	A>P	No	EVA
rs3389151905	156	D>H	No	EVA
rs3389168296	176	I>T	No	EVA
rs3389128615	209	E>K	No	EVA
rs3389138738	214	Y>H	No	EVA
rs3389168279	228	H>Y	No	EVA
rs3389128667	274	T>I	No	EVA
rs3411600442	332	V>L	No	EVA
rs3389163454	335	V>I	No	EVA
rs3389151910	352	V>D	No	EVA
rs3389177170	357	V>M	No	EVA
rs3389171338	406	N>D	No	EVA
rs3389135911	424	D>N	No	EVA
rs3389177183	434	P>S	No	EVA
rs3389128628	440	Q>K	No	EVA
rs3389166270	454	H>Y	No	EVA
rs50722940	474	P>T	No	EVA
rs3389102642	482	D>N	No	EVA
rs218879277	485	G>D	No	EVA
rs3402364591	512	V>G	No	EVA
rs3402588054	515	V>A	No	EVA
rs3402080593	515	V>I	No	EVA
rs26969697	518	R>Q	No	EVA
rs3389172006	521	S>T	No	EVA
rs3389161618	531	E>K	No	EVA
rs3389138746	540	D>N	No	EVA
rs222194660	544	P>L	No	EVA
rs3389168333	555	Q>*	No	EVA
rs234397025	560	M>V	No	EVA
rs252117266	577	D>Y	No	EVA
rs3401713648	591	D>N	No	EVA
rs3389166269	592	Q>H	No	EVA
rs3389128711	626	V>I	No	EVA
rs3389168291	637	A>S	No	EVA
rs3402307337	638	N>H	No	EVA
rs3401081306	639	G>W	No	EVA
rs3401081382	641	G>C	No	EVA
rs242282294	645	R>Q	No	EVA
rs3389171961	672	S>R	No	EVA
rs3389135864	689	R>G	No	EVA
rs48529858	747	L>P	No	EVA
rs3389159133	797	W>*	No	EVA

Type	Name	Position	InterPro Accession
domain	FAM83, N-terminal	15 - 308	IPR012461

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Nucleus	Detected predominantly in the cytosol Upon BMP stimulation, a small portion localizes the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

Name	Definition
BMP signaling pathway	The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9H4H8	FAM83D	Protein FAM83D	Homo sapiens (Human)	PR
Q9D7I8	Fam83d	Protein FAM83D	Mus musculus (Mouse)	PR