Q5SV66

PR
Gene name
Ccdc42
Protein name
Coiled-coil domain-containing protein 42
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:276920
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-316 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SV66

Entry ID Method Resolution Chain Position Source
AF-Q5SV66-F1 Predicted AlphaFoldDB

17 variants for Q5SV66

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389140421 40 P>T No EVA
rs3389167223 43 Q>K No EVA
rs3389162496 80 G>S No EVA
rs220156972 144 V>I No EVA
rs3389165687 145 K>M No EVA
rs3389163185 159 V>M No EVA
rs3389167457 160 V>M No EVA
rs3389181628 188 S>W No EVA
rs3389170291 227 R>C No EVA
rs3389172234 253 T>I No EVA
rs3389170340 268 Q>K No EVA
rs3389167615 270 V>M No EVA
rs3389156151 290 D>N No EVA
rs3389165726 291 M>V No EVA
rs237417090 304 T>A No EVA
rs256896376 313 Q>P No EVA
rs222795506 316 M>I No EVA

No associated diseases with Q5SV66

4 regional properties for Q5SV66

Type Name Position InterPro Accession
domain Cyclin, C-terminal domain 236 - 359 IPR004367
domain Cyclin, N-terminal 105 - 233 IPR006671
domain Cyclin-like domain 143 - 227 IPR013763-1
domain Cyclin-like domain 240 - 328 IPR013763-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton
  • Cell projection, cilium, flagellum
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Weakly expressed in the cytoplasm of round spermatids
  • In elongating spermatids, localizes to the manchette microtubules and the perinuclear ring
  • In the sperm flagellum, strongly expressed in the principle piece and also located to the connecting piece and weakly to the midpiece
  • Localizes to the centrosome in somatic cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQM8 CCDC42 Coiled-coil domain-containing protein 42 Bos taurus (Bovine) PR
Q96M95 CCDC42 Coiled-coil domain-containing protein 42 Homo sapiens (Human) PR
10 20 30 40 50 60
MSLGMMEEED LAEYFRLQYG ERLLQLLQKF PNVEEQSDSP SIQLLEKKKE AKIMQEAMEH
70 80 90 100 110 120
KKEAFQRRME TLNLRWEELG IKEEQLKAHI QKFEQFIQEN DQKRIRALKK ANKERELKRL
130 140 150 160 170 180
RLRELAKAKQ EMMALRLEHQ KLSVKLQDYA IFNKYLEKVV ENSEFEEIHE VIARYKTLVS
190 200 210 220 230 240
MHHDLMQSAQ EGQEKIERAK ARLARYMEEK DDEILQHNNE LARLQMRFDR ARSDVIFWES
250 260 270 280 290 300
RWAHIQNTAA KKTLLLGTIK MATLNLFQIV SKQLKESTQV SLEDTHKQLD MIQQFIQDLS
310
DIWTEVKKKE QQQVRM