A6QQM8

PR
Gene name
CCDC42
Protein name
Coiled-coil domain-containing protein 42
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:536427
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QQM8

Entry ID Method Resolution Chain Position Source
AF-A6QQM8-F1 Predicted AlphaFoldDB

86 variants for A6QQM8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs876500155 21 E>G No EVA
rs471079582 32 S>R No EVA
rs454260319 34 E>G No EVA
rs431912731 42 V>I No EVA
rs434128276 48 K>E No EVA
rs468869185 56 H>D No EVA
rs455272348 57 A>D No EVA
rs438303554 59 E>G No EVA
rs460491010 71 T>N No EVA
rs440522618 77 E>* No EVA
rs475074813 77 E>D No EVA
rs476108972 78 E>D No EVA
rs461560087 78 E>K No EVA
rs444607271 78 E>V No EVA
rs432669557 84 A>P No EVA
rs451371126 99 E>G No EVA
rs451371126 99 E>V No EVA
rs434697117 102 Q>* No EVA
rs465987444 107 A>D No EVA
rs446867487 108 L>R No EVA
rs481463512 110 K>T No EVA
rs451053493 117 L>H No EVA
rs467761908 117 L>I No EVA
rs482357795 120 Q>H No EVA
rs1117359773 122 M>I No EVA
rs480157347 128 A>G No EVA
rs443080325 131 E>G No EVA
rs473641469 132 M>R No EVA
rs456754794 134 V>I No EVA
rs451493308 139 H>R No EVA
rs465980568 143 S>G No EVA
rs455668885 143 S>R No EVA
rs435465342 145 K>Q No EVA
rs467800743 146 L>R No EVA
rs450892697 147 Q>E No EVA
rs450892697 147 Q>K No EVA
rs465382236 149 Y>C No EVA
rs482385294 149 Y>H No EVA
rs482385294 149 Y>N No EVA
rs480117129 155 Y>S No EVA
rs459767662 156 L>R No EVA
rs443115114 157 E>K No EVA
rs480696820 158 K>* No EVA
rs463204737 158 K>T No EVA
rs443159414 159 V>L No EVA
rs876598463 160 V>G No EVA
rs451342820 162 N>T No EVA
rs440884926 163 S>P No EVA
rs472421774 164 E>G No EVA
rs476737135 167 E>K No EVA
rs439676809 176 K>E No EVA
rs471237351 178 L>R No EVA
rs211235659 205 R>C No EVA
rs434288428 205 R>H No EVA
rs454531045 209 E>D No EVA
rs475264966 209 E>G No EVA
rs437546490 211 D>G No EVA
rs468943908 212 D>A No EVA
rs445758798 213 E>V No EVA
rs466627535 215 L>Q No EVA
rs481132359 216 Q>H No EVA
rs446568926 216 Q>P No EVA
rs875992886 217 H>P No EVA
rs461036020 218 N>T No EVA
rs483105047 219 N>K No EVA
rs450697526 219 N>S No EVA
rs462892654 222 A>V No EVA
rs439707856 223 R>G No EVA
rs439707856 223 R>S No EVA
rs471042553 225 Q>K No EVA
rs460758266 225 Q>R No EVA
rs475301886 226 M>R No EVA
rs440599832 226 M>V No EVA
rs455272529 227 R>H No EVA
rs438271681 228 F>L No EVA
rs475472823 229 D>A No EVA
rs451983125 231 A>S No EVA
rs432073965 233 S>G No EVA
rs466466840 234 D>E No EVA
rs451455066 244 H>P No EVA
rs472446457 248 T>S No EVA
rs453334599 279 F>L No EVA
rs436428466 280 V>L No EVA
rs467785625 288 Q>E No EVA
rs450929993 291 M>V No EVA
rs1117585560 314 I>V No EVA

No associated diseases with A6QQM8

3 regional properties for A6QQM8

Type Name Position InterPro Accession
domain CASTOR, ACT domain 72 - 140 IPR027795-1
domain CASTOR, ACT domain 262 - 322 IPR027795-2
domain CASTOR1, N-terminal 9 - 69 IPR040778

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton
  • Cell projection, cilium, flagellum
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Weakly expressed in the cytoplasm of round spermatids
  • In elongating spermatids, localizes to the manchette microtubules and the perinuclear ring
  • In the sperm flagellum, strongly expressed in the principle piece and also located to the connecting piece and weakly to the midpiece
  • Localizes to the centrosome in somatic cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96M95 CCDC42 Coiled-coil domain-containing protein 42 Homo sapiens (Human) PR
Q5SV66 Ccdc42 Coiled-coil domain-containing protein 42 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSLGIMEEED LAEYFRLQYG ERLLQLLQKF PSIEDQSDSP SVRLLEKKKE AKIMHHAMEQ
70 80 90 100 110 120
KKETFQRRME TLNLRWEELG IKEAQLKAHI QKFEQFIQEN DQKRIRALKK ANKERELKRQ
130 140 150 160 170 180
RMRELAKAKQ EMAVLRLEHQ RLSAKLQEYS IFNKYLEKVV ENSEFEEIHE VIARYKTLVS
190 200 210 220 230 240
MHHDLMQSAQ EGQEKIERAK ARLARYKEEK DDEILQHNNE LARLQMRFDR ARSDVIIWES
250 260 270 280 290 300
RWAHIQNTAA KKTLLLGTIK MATLNLFQIV SKQLKEATFV SLEDTHKQLD MIQQFIQDLS
310
DIWAEVKKKE LQQIRV