Q5RKZ7

PR
Gene name
Mocs1
Protein name
Molybdenum cofactor biosynthesis protein 1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:56738
EC number
4.1.99.22: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

417-509 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RKZ7

Entry ID Method Resolution Chain Position Source
AF-Q5RKZ7-F1 Predicted AlphaFoldDB

39 variants for Q5RKZ7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3413013261 52 E>K No EVA
rs3389469051 54 A>V No EVA
rs3389472032 74 I>L No EVA
rs3389448609 84 C>S No EVA
rs221840970 94 P>S No EVA
rs1132831976 112 R>H No EVA
rs3389382560 120 D>Y No EVA
rs3389460522 123 R>C No EVA
rs3407683029 135 V>E No EVA
rs3407746506 136 V>G No EVA
rs3389428567 136 V>L No EVA
rs3389428567 136 V>M No EVA
rs50807396 144 G>R No EVA
rs3406763334 163 L>Q No EVA
rs3407410421 164 L>M No EVA
rs3405944537 167 L>I No EVA
rs3406837300 167 L>R No EVA
rs3389382582 191 V>I No EVA
rs3389485780 203 I>F No EVA
rs3389469108 240 P>S No EVA
rs3389448577 244 R>H No EVA
rs3389382573 247 E>K No EVA
rs3408092920 269 D>A No EVA
rs3389471089 298 Q>L No EVA
rs3389465013 307 M>I No EVA
rs3389465026 312 C>* No EVA
rs221323050 333 N>S No EVA
rs3407746516 340 D>P No EVA
rs3389481022 364 R>L No EVA
rs3389471109 381 I>T No EVA
rs3389428516 443 G>C No EVA
rs3389471076 444 S>F No EVA
rs49127146 531 D>N No EVA
rs3389471133 548 S>R No EVA
rs3406837341 565 H>R No EVA
rs263832157 572 R>H No EVA
rs1133673473 582 R>Q No EVA
rs3389382553 611 V>I No EVA
rs3389419178 616 V>M No EVA

No associated diseases with Q5RKZ7

5 regional properties for Q5RKZ7

Type Name Position InterPro Accession
conserved_site MoaA/NifB/PqqE, iron-sulphur binding, conserved site 76 - 87 IPR000385
domain Molybdopterin cofactor biosynthesis C (MoaC) domain 493 - 628 IPR002820
domain Elp3/MiaA/NifB-like, radical SAM core domain 70 - 273 IPR006638
domain Radical SAM 64 - 279 IPR007197
domain Molybdenum cofactor biosynthesis protein A-like, twitch domain 242 - 376 IPR010505

Functions

Description
EC Number 4.1.99.22 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
cyclic pyranopterin monophosphate synthase activity Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
GTP 3',8'-cyclase activity Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JQD7 MOCS1 Molybdenum cofactor biosynthesis protein 1 Bos taurus (Bovine) PR
Q8IQF1 Mocs1 Molybdenum cofactor biosynthesis protein 1 Drosophila melanogaster (Fruit fly) PR
Q9NZB8 MOCS1 Molybdenum cofactor biosynthesis protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MAARPAFGIV RQLLRSNARG CSSGAPVTQP RPGEPSRPTR EGLSLRLQFL QEHAAPFSAF
70 80 90 100 110 120
LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAD LLTTEEILTL ARLFVKEGVD
130 140 150 160 170 180
KIRLTGGEPL IRPDVVDIVA RLHGLEGLRT IGLTTNGINL ARLLPRLQQA GLNAVNISLD
190 200 210 220 230 240
TLVPAKFEFI VRRKGFHKVM EGIHKAIELG YKPVKVNCVV MRGLNEDELL DFVALTEGLP
250 260 270 280 290 300
LDVRFIEYMP FDGNKWNFKK MVSYKEMLDT IRQRWPGLEK LPEEDSSTAK AFKIPGFQGQ
310 320 330 340 350 360
ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEEE LLRIIGAAVG
370 380 390 400 410 420
RKKRQHAGMF NIAQMKNRPM ILIGVLLMLQ DSPPARWSNF SWDPLRVRNP SARQCLSDQM
430 440 450 460 470 480
ASLWKRHCIP KALPLSQQCL GSGSPQRHYS SYPDPDTHSK CLSTGSQAPD APSGPGPTSN
490 500 510 520 530 540
QLTHVDSAGR ASMVDVGGKP ETERVAVASA MVLLGPVAFK LVQQNQLKKG DALVVAQLAG
550 560 570 580 590 600
VQAAKLTSQL IPLCHHVALS HVQVHLELDS TRHAVLIQAS CRARGPTGVE MEALTSAAMA
610 620 630
ALTVYDMCKA VSRDIVVTEV KLISKTGGQR GDFHRA