Q1JQD7

PR
Gene name
MOCS1
Protein name
Molybdenum cofactor biosynthesis protein 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281917
EC number
4.1.99.22: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

420-497 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1JQD7

Entry ID Method Resolution Chain Position Source
AF-Q1JQD7-F1 Predicted AlphaFoldDB

218 variants for Q1JQD7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs133871311 9 V>G No EVA
rs476256438 10 V>G No EVA
rs451392568 12 R>W No EVA
rs439351135 13 V>G No EVA
rs136684662 14 L>P No EVA
rs435491514 15 R>I No EVA
rs468399708 15 R>S No EVA
rs456517495 16 A>S No EVA
rs464587179 18 V>G No EVA
rs479180739 29 Q>K No EVA
rs448789016 34 E>G No EVA
rs448789016 34 E>V No EVA
rs481760161 37 V>L No EVA
rs453750604 41 S>A No EVA
rs876563456 41 S>C No EVA
rs453750604 41 S>P No EVA
rs474873787 48 G>A No EVA
rs437934938 49 E>D No EVA
rs876629294 49 E>G No EVA
rs464439045 50 H>P No EVA
rs470933341 51 A>S No EVA
rs470933341 51 A>T No EVA
rs433927594 52 A>P No EVA
rs467039452 53 P>A No EVA
rs448519312 53 P>H No EVA
rs463201057 54 F>L No EVA
rs450982619 55 S>P No EVA
rs477533947 56 A>P No EVA
rs439172684 57 F>I No EVA
rs472183955 57 F>S No EVA
rs460097231 58 L>P No EVA
rs441748645 59 T>A No EVA
rs474696328 62 F>V No EVA
rs519694929 65 H>R No EVA
rs456361599 66 H>Y No EVA
rs437771603 67 S>T No EVA
rs452380744 70 R>Q No EVA
rs467034979 71 I>L No EVA
rs448375610 71 I>M No EVA
rs467034979 71 I>V No EVA
rs436524472 74 T>P No EVA
rs469435190 74 T>S No EVA
rs436524472 74 T>S No EVA
rs451019464 76 R>G No EVA
rs477368311 77 C>R No EVA
rs477368311 77 C>S No EVA
rs459085823 78 N>K No EVA
rs432980624 81 C>* No EVA
rs447151743 81 C>S No EVA
rs453833557 90 V>D No EVA
rs468441471 101 T>A No EVA
rs450120815 101 T>I No EVA
rs437955669 111 F>C No EVA
rs446170456 117 D>G No EVA
rs460790244 125 E>K No EVA
rs469781458 129 R>Q No EVA
rs448564222 131 D>Y No EVA
rs455771972 135 I>M No EVA
rs516532501 140 R>H No EVA
rs472546447 147 T>I No EVA
rs519506380 174 I>V No EVA
rs435064509 207 G>V No EVA
rs465033475 213 V>A No EVA
rs465033475 213 V>G No EVA
rs432055023 213 V>L No EVA
rs446570948 214 N>S No EVA
rs434661789 215 C>G No EVA
rs467462040 215 C>S No EVA
rs449191398 216 V>L No EVA
rs463706581 218 M>T No EVA
rs478327654 219 R>L No EVA
rs441409154 220 G>C No EVA
rs474510175 222 N>T No EVA
rs462400762 224 D>N No EVA
rs443890372 224 D>V No EVA
rs456863952 229 F>V No EVA
rs432087544 233 T>P No EVA
rs437060836 245 Y>* No EVA
rs449207225 245 Y>C No EVA
rs467398906 245 Y>N No EVA
rs470224545 246 M>I No EVA
rs445163134 247 P>H No EVA
rs459799258 248 F>L No EVA
rs447891278 249 D>G No EVA
rs467001611 250 G>D No EVA
rs448738489 252 K>E No EVA
rs436673924 252 K>N No EVA
rs468178426 253 W>G No EVA
rs468178426 253 W>R No EVA
rs449639137 254 N>K No EVA
rs482805486 256 K>T No EVA
rs457791653 257 K>N No EVA
rs478845505 267 T>P No EVA
rs460316471 270 Q>K No EVA
rs441919370 275 L>Q No EVA
rs441919370 275 L>R No EVA
rs462925493 276 E>D No EVA
rs470909797 279 P>A No EVA
rs452536538 280 E>G No EVA
rs473439140 281 E>D No EVA
rs440456792 281 E>G No EVA
rs455097103 283 S>A No EVA
rs455097103 283 S>P No EVA
rs455097103 283 S>T No EVA
rs137653152 285 T>P No EVA
rs137653152 285 T>S No EVA
rs432088746 288 A>T No EVA
rs452960339 290 K>I No EVA
rs434691319 290 K>N No EVA
rs437226482 298 V>D No EVA
rs455722573 298 V>F No EVA
rs466389953 319 A>T No EVA
rs447755093 320 D>G No EVA
rs480962469 321 G>R No EVA
rs477249522 325 V>G No EVA
rs458763327 328 F>I No EVA
rs446970907 329 G>V No EVA
rs479938523 334 S>C No EVA
rs482409452 337 D>E No EVA
rs442959340 337 D>H No EVA
rs464093285 338 H>R No EVA
rs439108105 339 L>P No EVA
rs451981128 342 G>R No EVA
rs473035208 343 A>D No EVA
rs436200493 344 S>P No EVA
rs468998827 345 E>* No EVA
rs457109691 346 E>D No EVA
rs465396237 349 L>P No EVA
rs479964983 350 R>G No EVA
rs467886468 350 R>S No EVA
rs439145282 352 I>M No EVA
rs463928299 352 I>T No EVA
rs482448147 352 I>V No EVA
rs458559037 354 A>S No EVA
rs454584894 356 V>G No EVA
rs473031808 356 V>L No EVA
rs442463193 358 R>G No EVA
rs475437354 358 R>K No EVA
rs456084838 363 H>D No EVA
rs444045431 364 A>P No EVA
rs471786534 381 E>G No EVA
rs453250719 382 L>I No EVA
rs434884652 384 L>F No EVA
rs467915459 386 R>C No EVA
rs467915459 386 R>G No EVA
rs437423091 389 S>T No EVA
rs478526172 391 P>R No EVA
rs458482134 393 L>V No EVA
rs479203875 394 P>Q No EVA
rs481857485 396 T>P No EVA
rs481857485 396 T>S No EVA
rs463527163 397 F>V No EVA
rs438704548 398 R>G No EVA
rs471669762 398 R>M No EVA
rs453123853 399 N>H No EVA
rs441291807 400 S>C No EVA
rs455862997 401 L>H No EVA
rs455862997 401 L>P No EVA
rs437259740 404 Q>E No EVA
rs437259740 404 Q>K No EVA
rs470395931 404 Q>P No EVA
rs433480540 405 V>D No EVA
rs451834214 405 V>L No EVA
rs466524461 410 V>E No EVA
rs479240699 417 V>G No EVA
rs467184095 427 Q>R No EVA
rs481938010 431 V>D No EVA
rs438628306 432 A>D No EVA
rs478054136 433 Q>L No EVA
rs459677989 436 L>R No EVA
rs441130145 437 G>A No EVA
rs474210053 440 L>H No EVA
rs455699682 442 Q>H No EVA
rs443747702 448 H>D No EVA
rs476701454 448 H>R No EVA
rs451696962 458 L>P No EVA
rs433414603 462 E>D No EVA
rs522565126 464 Q>R No EVA
rs466302664 479 L>Q No EVA
rs454310682 480 T>I No EVA
rs435814344 483 D>G No EVA
rs467222819 489 A>S No EVA
rs448748684 490 M>I No EVA
rs518896260 504 V>M No EVA
rs132900778 508 V>G No EVA
rs469946898 513 P>A No EVA
rs444874313 514 V>L No EVA
rs478083497 521 E>Q No EVA
rs459508780 533 A>S No EVA
rs447606137 535 L>M No EVA
rs480468442 536 A>S No EVA
rs462151483 537 G>V No EVA
rs443658415 538 I>F No EVA
rs472851489 550 L>P No EVA
rs454148030 559 V>A No EVA
rs475065363 567 R>P No EVA
rs469753326 573 V>G No EVA
rs444947414 577 S>F No EVA
rs110188539 579 R>Q No EVA
rs465969819 581 R>G No EVA
rs465969819 581 R>W No EVA
rs447445076 585 G>R No EVA
rs480404004 586 V>E No EVA
rs3423513535 594 A>T No EVA
rs1115210885 600 A>T No EVA
rs462086068 602 Y>H No EVA
rs797149363 608 V>I No EVA
rs458031190 610 R>S No EVA
rs439701735 614 L>V No EVA
rs472455327 617 I>S No EVA
rs460587556 618 K>* No EVA
rs474987857 619 L>R No EVA
rs456709858 620 V>A No EVA
rs456709858 620 V>D No EVA
rs451147045 623 T>I No EVA
rs476271129 623 T>P No EVA
rs479022053 631 H>L No EVA
rs479022053 631 H>R No EVA

No associated diseases with Q1JQD7

10 regional properties for Q1JQD7

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 672 - 905 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1345 - 1600 IPR003439-2
domain AAA+ ATPase domain 696 - 898 IPR003593-1
domain AAA+ ATPase domain 1371 - 1577 IPR003593-2
domain ABC transporter type 1, transmembrane domain 326 - 613 IPR011527-1
domain ABC transporter type 1, transmembrane domain 1027 - 1308 IPR011527-2
conserved_site ABC transporter-like, conserved site 805 - 819 IPR017871-1
conserved_site ABC transporter-like, conserved site 1502 - 1516 IPR017871-2
domain ABC transporter C family, six-transmembrane helical domain 2 1023 - 1320 IPR044726
domain ABC transporter C family, six-transmembrane helical domain 1 327 - 621 IPR044746

Functions

Description
EC Number 4.1.99.22 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
cyclic pyranopterin monophosphate synthase activity Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
GTP 3',8'-cyclase activity Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IQF1 Mocs1 Molybdenum cofactor biosynthesis protein 1 Drosophila melanogaster (Fruit fly) PR
Q9NZB8 MOCS1 Molybdenum cofactor biosynthesis protein 1 Homo sapiens (Human) PR
Q5RKZ7 Mocs1 Molybdenum cofactor biosynthesis protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAQPVSRVV RRVLRAGVRS CSSGAPVTQP CPGEPVVEVL SRPRPFLGEH AAPFSAFLTD
70 80 90 100 110 120
SFGRHHSYLR ISLTERCNLR CQYCMPEEGV PLTPKADLLT TEEILTLARL FVKEGVDKIR
130 140 150 160 170 180
LTGGEPLIRP DVVDIVAQLR QLEGLRTIGI TTNGINLARL LPQLQKAGLS AINISLDTLV
190 200 210 220 230 240
PAKFEFIVRR KGFHKVMEGI HKAIELGYSP VKVNCVVMRG LNEDELLDFV ALTEGLPLDV
250 260 270 280 290 300
RFIEYMPFDG NKWNFKKMVS YKEMLDTLRQ QWPELEKLPE EESSTAKAFK IPGFRGQVSF
310 320 330 340 350 360
ITSMSEHFCG TCNRLRITAD GNLKVCLFGN SEVSLRDHLR AGASEEELLR VIGAAVGRKK
370 380 390 400 410 420
RQHAGMFNIS QMKNRPMILI ELFLMRQDSP PALPSTFRNS LRVQVLRHRV SFSSQMVTLW
430 440 450 460 470 480
KGGGVPQAPL VAQRWLGSSL PQRHFSSHLD SDANPKCLSP TEPQAPAASS GPLPDSDQLT
490 500 510 520 530 540
HVDTEGRMAM VDVGRKPDTE RVAVASAVVL LGPVAFKLIQ ENQLKKGDAL AVAQLAGIQA
550 560 570 580 590 600
AKLTSQLIPL CHHVALSHVQ VQLELDRTRH AAVIQASCRA RGPTGVEMEA LTSAAVAALA
610 620 630
LYDMCKAVSR DIVLAEIKLV SKTGGQRGDF HRT