Q5RKG2

PR
Gene name
Hcfc2
Protein name
Host cell factor 2
Names
HCF-2, C2 factor
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:314704
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

347-505 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RKG2

Entry ID Method Resolution Chain Position Source
AF-Q5RKG2-F1 Predicted AlphaFoldDB

3 variants for Q5RKG2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs196962709 463 V>A No EVA
rs199080171 473 T>A No EVA
rs106016419 581 K>Q No EVA

No associated diseases with Q5RKG2

3 regional properties for Q5RKG2

Type Name Position InterPro Accession
domain Fibronectin type III 357 - 606 IPR003961-1
domain Fibronectin type III 609 - 709 IPR003961-2
repeat Kelch repeat type 1 22 - 59 IPR006652

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
MLL1 complex A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
MLL1/2 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

1 GO annotations of molecular function

Name Definition
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

3 GO annotations of biological process

Name Definition
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y5Z7 HCFC2 Host cell factor 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTVTNQWF
70 80 90 100 110 120
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPQPPPS
130 140 150 160 170 180
GLPPCPRLGH SFSLYGNKCY LFAGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSVP
190 200 210 220 230 240
ATKGTVPSPR ESHTAVIYCK RDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT
250 260 270 280 290 300
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TENSPHDCEW RCTSSFSYLN LDTAEWTTLV
310 320 330 340 350 360
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP
370 380 390 400 410 420
SQVQLIKATT NSFHVKWDEV PTVEGYLLQL NTDLTHQAAS PDASAAPNTL GGRTDPHRQG
430 440 450 460 470 480
SNSILHNSVS DPANCTKPEH TAVAARGMSL KSKPDSRAAD SSVALHSPLA PNTSNNNSCM
490 500 510 520 530 540
ADMLWKSEVD EICALPATKI SRVEAHAAAT PFSKETPSNP VAILKAEQWC DVGIFKNNTA
550 560 570 580 590 600
LVSQFYLLPK GKQSMSKVGN ADVPDYSLLK KQDLVPGTVY KFRVAAINGC GIGPFSKLSE
610 620 630 640 650 660
FKTCIPGFPG APSTVRISKN VEGIHLSWEP PTSPSGNILE YSAYLAIRTA QVQDNPSQLV
670 680 690 700 710 720
FMRIYCGLKT SCIVTAGQLA NAHIDYTSRP AIVFRISAKN EKGYGPATQV RWLQGNSKKA
PLS