Q5PQS3

PR
Gene name
Veph1
Protein name
Ventricular zone-expressed PH domain-containing protein homolog 1
Names
Protein melted homolog
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361954
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5PQS3

Entry ID Method Resolution Chain Position Source
AF-Q5PQS3-F1 Predicted AlphaFoldDB

3 variants for Q5PQS3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3319573111 226 A>T No EVA
rs199206797 540 P>L No EVA
rs106553044 692 E>K No EVA

No associated diseases with Q5PQS3

1 regional properties for Q5PQS3

Type Name Position InterPro Accession
domain Pleckstrin homology domain 716 - 820 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-5-phosphate binding Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.

3 GO annotations of biological process

Name Definition
negative regulation of SMAD protein signal transduction Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14D04 VEPH1 Ventricular zone-expressed PH domain-containing protein homolog 1 Homo sapiens (Human) PR
A1A535 Veph1 Ventricular zone-expressed PH domain-containing protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MHQLFRLVLG QKDLSRAGDL FSLDDAEIED SLTEALEQIK VISSSLDYQT NNNDQAVVEI
70 80 90 100 110 120
CITRITTAIR ETESIEKHAR ALVGLWDSCL EHNLRPAGKD EDTPHAKIAS DIMSCILQNY
130 140 150 160 170 180
NRTPVMVLAV PIAVKFLHRG SKELCRNMSN YLSLAAITKA DLLADHTEGI VKSILQGNAM
190 200 210 220 230 240
LLRVLPAVYE KQPQPINRHL AELLALMSQL EQTEQYHLLR LLHVAAKRKD VEVVQKCVPF
250 260 270 280 290 300
LIRNLKESTY NDIILNILIE IAGHEPLALN SFLPMLKEIA EQFPYLTGQM ARIFGAVGHV
310 320 330 340 350 360
DEERARSCLR YLVSQLANME HSFHHILLLE IKSLTDAFSS ILGPHSRDIF RMSNSFTNIA
370 380 390 400 410 420
KLLSRQLENS KAESGRRRTG TEVSFPEKFR EPKTMEPKSE DHEKLQVKIQ AFEDKINAES
430 440 450 460 470 480
HTPGSVRRYS LDHVSKEERK NVRFSRSRSL ALNTVLTNSV NVEDGEIEGK TGMHASISLS
490 500 510 520 530 540
EIDPPGHGIG KVPFKTDTHG SQLRNSSASH PSIIHSEPEN MPETFKENVQ EEIPEAAISP
550 560 570 580 590 600
VEYQDKLYLH LKENLSKVKA YALEIAKKVP IPDQCTIEDN TRSCVAKLFF TCSLKGHYCL
610 620 630 640 650 660
YSKSSFTLVS QAPQPWIQIM FLFQQSLFPE PLSIQSGSVQ FLKALWEKTQ GTGTHSFEVA
670 680 690 700 710 720
MTESTFPQQK DLDQLQLHLE EVRFFDVFGF SETAGAWQCF MCNNPEKATV INQDGQPLIE
730 740 750 760 770 780
GKLKEKQVRW KFIKRWKTRY FTLAGNQLLF QKGKSDDPDD SPIELSKVQS VKAVAKKRRD
790 800 810 820 830
RSLPRAFEIF TDNKTYVFKA KDEKNAEEWL QCINVALAQA KERESREVTT YL