A1A535

PR
Gene name
Veph1 (Veph)
Protein name
Ventricular zone-expressed PH domain-containing protein 1
Names
Protein melted homolog
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72789
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

335-552 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1A535

Entry ID Method Resolution Chain Position Source
AF-A1A535-F1 Predicted AlphaFoldDB

37 variants for A1A535

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3393166758 9 L>F No EVA
rs3392942770 11 Q>P No EVA
rs3388635171 41 V>E No EVA
rs3388636588 87 D>G No EVA
rs3388622182 92 H>Y No EVA
rs3388634595 208 S>T No EVA
rs3388615062 231 V>E No EVA
rs3388626701 256 N>Y No EVA
rs3388622144 289 Q>L No EVA
rs3388633975 340 S>F No EVA
rs235022309 393 N>K No EVA
rs216573640 396 E>K No EVA
rs31512068 460 V>M No EVA
rs3388634676 469 E>D No EVA
rs3388632562 470 K>M No EVA
rs236120073 475 A>V No EVA
rs36271080 500 G>E No EVA
rs255242982 516 T>I No EVA
rs232051022 523 E>K No EVA
rs3388632179 528 N>H No EVA
rs3392941777 538 T>S No EVA
rs30404479 541 I>V No EVA
rs3393108118 561 Y>* No EVA
rs245102252 607 I>T No EVA
rs227699500 619 V>I No EVA
rs3388630349 631 P>S No EVA
rs3388638049 639 V>M No EVA
rs3388634701 656 S>G No EVA
rs3388630780 667 P>S No EVA
rs3388628657 688 F>LR* No EVA
rs3388625147 691 S>R No EVA
rs3388628297 722 K>T No EVA
rs3388638031 725 E>G No EVA
rs13477164 739 H>R No EVA
rs223461791 762 S>P No EVA
rs3388632514 776 A>T No EVA
rs3388615082 821 A>T No EVA

No associated diseases with A1A535

1 regional properties for A1A535

Type Name Position InterPro Accession
domain Pleckstrin homology domain 716 - 821 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-5-phosphate binding Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.

3 GO annotations of biological process

Name Definition
negative regulation of SMAD protein signal transduction Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14D04 VEPH1 Ventricular zone-expressed PH domain-containing protein homolog 1 Homo sapiens (Human) PR
Q5PQS3 Veph1 Ventricular zone-expressed PH domain-containing protein homolog 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MHQLFRLVLG QKDLSKAGDL FSLDDAEIED SLTEALEQIK VISSSLDYQT NNNDQAVVEI
70 80 90 100 110 120
CITRITTAIR ETESIEKHAR ALVGLWDSCL EHNLRPAGKD EDTPHAKIAS DIMSCILQNY
130 140 150 160 170 180
NRTPVMVLAV PIAVKFLHRG SKELCRNMSN YLSLAAITKA DLLADHTEGI IKSILQGNAM
190 200 210 220 230 240
LLRVLPAVYE KQPQPINRHL AELLALMSQL EQTEQYHLLR LLHVAAKRKD VEVVQKCVPF
250 260 270 280 290 300
LIRNLKDSTY NDIILNILIE IAGHEPLALN SFLPMLKEIA EQFPYLTGQM ARIFGAVGHV
310 320 330 340 350 360
DEERARSCLR YLVSQLANME HPFHHILLLE IKSITDAFSS ILGPHSRDIF RMSNSFTNIA
370 380 390 400 410 420
KLLSRQLENS KADSSRRKTS TEVSIPEKLR ELNSMEPESE DHEKLQVKIQ AFEDKINAES
430 440 450 460 470 480
NTPGSGRRYS LDHISKEERK SIRFSRSRSL ALNTVLTNGV SVEDNEVEEK AGMHASISLS
490 500 510 520 530 540
QIDPLSHGIG KLPFKTDTHG SPLRNSSASH PSIIHTEPET MPETFKENIQ EEILEAATSP
550 560 570 580 590 600
IEYQDKLYLH LRENLSKVKA YALEIAKKVP IPDQCTIEDT MRSCVAKLFF TCSLKGHYCL
610 620 630 640 650 660
YSKSSFILVS QAPQPWIQVM FLSQQSLFPE PLSIQSGSVQ FLKALWEKTQ DTGAHSFEVA
670 680 690 700 710 720
MTESTFPQQK DLEQLQLHLE EVRFFDVFGF SETAGAWQCF MCNNPEKATV VNQDGQPLIE
730 740 750 760 770 780
GKLKEKQVRW KFIKRWKTHY FTLAGNQLLF QKGKSKDDPD DSPIELSKVQ SVKAVAKKRR
790 800 810 820 830
DRSLPRAFEI FTDSKTYVFK AKDEKNAEEW LQCINVALAQ AKERESREVT TYL