Q5M883
Gene name |
Clic2 |
Protein name |
Chloride intracellular channel protein 2 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:294141 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5M883
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5M883-F1 | Predicted | AlphaFoldDB |
No variants for Q5M883
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5M883 | |||||
No associated diseases with Q5M883
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of ryanodine-sensitive calcium-release channel activity | Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
| positive regulation of binding | Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASLALNTQA | DPEIELFVKA | GSDGESIGNC | PFCQRLFMIL | WLKGVKFNVT | TIDTARKPEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKDLAPGTNP | PFLIYNKELK | TDFIKIEEFL | EKTLAPPRYP | HLSPKYKESF | DVGCNLFAKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SAYIKNTQKE | ANKNFEKSLL | REFKRLDDYL | NTPLLDEIDP | DSTEERTLSR | RLFLDGDQLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LADCSLLPKL | NIIKVAAKKY | RDFDIPAEFS | GVWRYLHNAY | AREEFAHTCP | EDKEIENTYA |
| SVAKQ |