O45405

PR
Gene name
exl-1 (F26H11.5)
Protein name
Chloride intracellular channel exl-1
Names
Exc-4-like protein
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F26H11.5
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-132 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O45405

Entry ID Method Resolution Chain Position Source
AF-O45405-F1 Predicted AlphaFoldDB

No variants for O45405

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O45405

No associated diseases with O45405

No regional properties for O45405

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O45405

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane
  • Lysosome membrane
  • Golgi apparatus membrane
  • Can be translocated to membranes, possibly as integral membrane proteins, with chloride channel activity (By similarity)
  • Localizes to lysosomal membranes in the intestine, and to Golgi apparatus in neurons and muscle
  • It also localizes to dense bodies, a transmembrane structure which links the muscle cytoskeleton to the neighboring hypodermis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
chloride channel complex An ion channel complex through which chloride ions pass.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
muscle cell projection membrane The portion of the plasma membrane surrounding a muscle cell projection.
striated muscle dense body A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.

2 GO annotations of molecular function

Name Definition
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
voltage-gated ion channel activity Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

2 GO annotations of biological process

Name Definition
chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15247 CLIC2 Chloride intracellular channel protein 2 Homo sapiens (Human) PR
Q5M883 Clic2 Chloride intracellular channel protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPTFSLWLPA GSNNVHPCGD PYAHHLFMRC LYHAKHDPTM KFDVKTTNVN KTSQEFKNTG
70 80 90 100 110 120
LRRMPGISAE ESGETQTFET EDDILDFLEY LKPERGDDEE AENATCDLFR QFARFVKDVE
130 140 150 160 170 180
HRDTAFNTEL LRLDKYLSEQ ETKFLISDDV THIDCLVLTR LHSIRVAAKM LKNYEIPADL
190 200 210 220 230
SHVLDYLKAG YATEMFRVSC PSDQEIVLHW TELKDTPRLS AKDRAKLVRE EPVFSFSV