Q5IS37
SS
Gene name |
NTRK3 |
Protein name |
NT-3 growth factor receptor |
Names |
EC 2.7.10.1 , Neurotrophic tyrosine kinase receptor type 3 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
ptr:467751 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
AMP-activated protein kinase (AMPK) acts as an energy sensor, being activated by metabolic stresses and regulating cellular metabolism. AMPK is a heterotrimer consisting of a catalytic alpha subunit and two regulatory subunits, beta and gamma. AMPK alpha subunit contains an autoinhibitory domain that inhibits the N-terminal kinase domain. Autoinhibitory region of AMPK alpha are not only responsible for kinase autoinhibition, but may also be responsible for full-length kinase degradation.
Autoinhibitory domains (AIDs)
Target domain |
538-810 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
696-721 (Activation loop from InterPro)
Target domain |
538-814 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Arevalo JC et al. (2000) "TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor", Molecular and cellular biology, 20, 5908-16
- Artim SC et al. (2012) "Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family", The Biochemical journal, 448, 213-20
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
- Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96
Autoinhibited structure
Activated structure
1 structures for Q5IS37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5IS37-F1 | Predicted | AlphaFoldDB |
No variants for Q5IS37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5IS37 | |||||
No associated diseases with Q5IS37
12 regional properties for Q5IS37
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPS motif | 697 - 749 | IPR000203 |
| domain | Cysteine-rich flanking region, C-terminal | 187 - 236 | IPR000483 |
| repeat | Leucine-rich repeat | 85 - 141 | IPR001611 |
| domain | GPCR, family 2, extracellular hormone receptor domain | 323 - 418 | IPR001879 |
| repeat | Leucine-rich repeat, typical subtype | 79 - 103 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 104 - 127 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 128 - 151 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 152 - 175 | IPR003591-4 |
| domain | Immunoglobulin subtype | 249 - 342 | IPR003599 |
| domain | Immunoglobulin-like domain | 242 - 340 | IPR007110 |
| domain | Immunoglobulin I-set | 247 - 340 | IPR013098 |
| domain | GPCR, family 2-like, transmembrane domain | 756 - 1050 | IPR017981 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| neurotrophin binding | Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. |
| neurotrophin receptor activity | Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cellular response to nerve growth factor stimulus | A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| Q7YR43 | DDR1 | Epithelial discoidin domain-containing receptor 1 | Pan troglodytes (Chimpanzee) | SS |
| Q24488 | Ror | Tyrosine-protein kinase transmembrane receptor Ror | Drosophila melanogaster (Fruit fly) | SS |
| Q9V6K3 | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2 | Drosophila melanogaster (Fruit fly) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| G5EGK5 | cam-1 | Tyrosine-protein kinase receptor cam-1 | Caenorhabditis elegans | SS |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFG1 | At3g53590 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGFKRGYDG | KIAGLYDLDK | TLGRGHFAVV | KLARHVFTGE | KVAVKVIDKT | KLDTLATGHL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FQEVRCMKLV | QHPNIVRLYE | VIDTQTKLYL | ILELGDGGDM | FDYIMKHEEG | LNEDLAKKYF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQIVHAISYC | HKLHVVHRDL | KPENVVFFEK | QGLVKLTDFG | FSNKFQPGKK | LTTSCGSLAY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAPEILLGDE | YDAPAVDIWS | LGVILFMLVC | GQPPFQEAND | SETLTMIMDC | KYTVPSHVSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ECKDLITRML | QRDPKRRASL | EEIENHPWLQ | GVDPSPATKY | NIPLVSYKNL | SEEEHNSIIQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RMVLGDIADR | DAIVEALETN | RYNHITATYF | LLAERILREK | QEKEIQTRSA | SPSNIKAQFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QSWPTKIDVP | QDLEDDLTAT | PLSHATVPQS | PARAADSVLN | GHRSKGLCDS | AKKDDLPELA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GPALSTVPPA | SLKPTASGRK | CLFRVEEDEE | EDEEDKKPMS | LSTQVVLRRK | PSVTNRLTSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KSAPVLNQIF | EEGESDDEFD | MDENLPPKLS | RLKMNIASPG | TVHKRYHRRK | SQGRGSSCSS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SETSDDDSES | RRRLDKDSGF | TYSWHRRDSS | EGPPGSEGDG | GGQSKPSNAS | GGVDKASPSE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NNAGGGSPSS | GSGGNPTNTS | GTTRRCAGPS | NSMQLASRSA | GELVESLKLM | SLCLGSQLHG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| STKYIIDPQN | GLSFSSVKVQ | EKSTWKMCIS | STGNAGQVPA | VGGIKFFSDH | MADTTTELER |
| 730 | 740 | 750 | 760 | ||
| IKSKNLKNNV | LQLPLCEKTI | SVNIQRNPKE | GLLCASSPAS | CCHVI |