Q5IBH6

PR
Gene name
Spdye4a
Protein name
Speedy protein E4A
Names
Rapid inducer of G2/M progression in oocytes E4A, RINGO E4A, mSpy/Ringo E4A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74673
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5IBH6

Entry ID Method Resolution Chain Position Source
AF-Q5IBH6-F1 Predicted AlphaFoldDB

18 variants for Q5IBH6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs243798726 14 Q>* No EVA
rs3388803261 14 Q>H No EVA
rs225191480 14 Q>R No EVA
rs3396172292 25 F>V No EVA
rs257970896 29 R>G No EVA
rs3411667022 38 A>T No EVA
rs36850716 55 T>I No EVA
rs3388803263 57 P>L No EVA
rs583975669 93 S>L No EVA
rs226895145 94 L>S No EVA
rs1132839570 108 P>L No EVA
rs3388808622 112 W>L No EVA
rs236569902 116 M>T No EVA
rs38810574 128 R>C No EVA
rs3388792486 149 V>G No EVA
rs3388806994 185 R>M No EVA
rs3388795281 236 M>L No EVA
rs3388798338 244 R>L No EVA

No associated diseases with Q5IBH6

No regional properties for Q5IBH6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5IBH6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
acetylcholine receptor regulator activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
positive regulation of cyclin-dependent protein serine/threonine kinase activity Any process that activates or increases the frequency, rate or extent of CDK activity.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5IBH7 Spdya Speedy protein A Mus musculus (Mouse) PR
Q8R496 Spdya Speedy protein A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGEGTPGVDS ARVQEEGGRD QSLGFVEGRI QVGRIVTAGQ LSLCSEEQSP QPGITRPSPG
70 80 90 100 110 120
VVVDGESSGL AEPRVEATPQ PPSSIQKRKR DESLDSEDDL AELFEPDPQP VWSVEMLCGL
130 140 150 160 170 180
RMRLKRRRVS TVRPEHHKVF TKLLEDPVVK KFLTWDKMLR VSDKYLLSMV IAYFSRAGLF
190 200 210 220 230 240
SWQYRPIHFF LALYLANDME EDNQAPKQDI FYFLYGKSYA QRPMFHKLRF QFIRSMGWKI
250 260
WVSREECEEI QAYNPDLWVW ARDRTNLT