Q5I0C5

PR
Gene name
Mtfmt
Protein name
Methionyl-tRNA formyltransferase, mitochondrial
Names
MtFMT
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:315763
EC number
2.1.2.9: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5I0C5

Entry ID Method Resolution Chain Position Source
AF-Q5I0C5-F1 Predicted AlphaFoldDB

No variants for Q5I0C5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5I0C5

No associated diseases with Q5I0C5

3 regional properties for Q5I0C5

Type Name Position InterPro Accession
domain Formyl transferase, N-terminal 113 - 215 IPR002376
domain Formyl transferase, C-terminal 240 - 344 IPR005793
domain Methionyl-tRNA formyltransferase, N-terminal domain 43 - 239 IPR041711

Functions

Description
EC Number 2.1.2.9 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
methionyl-tRNA formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.

1 GO annotations of biological process

Name Definition
conversion of methionyl-tRNA to N-formyl-methionyl-tRNA The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O77480 MTFMT Methionyl-tRNA formyltransferase, mitochondrial Bos taurus (Bovine) PR
Q96DP5 MTFMT Methionyl-tRNA formyltransferase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MLLPRRCWGP WLAGRRPRCS CQSPAGFSGK DRRSSRVREK PPWRVLFFGT DHFAREALRA
70 80 90 100 110 120
LHAARDNKEE KLIEKLEVVT VPSISPKGLP VKQYAIQSQL PVYEWPDMGS GEYDVGVVAS
130 140 150 160 170 180
FGRLLSEALI LKFPYGILNV HPSCLPRWRG PAPIIHTVLH GDTVTGVTIM QVRPKRFDVG
190 200 210 220 230 240
PILKQETVAV PPKSTSKELE AVLSKLGANM LISVLKNLPE SLNNGRPQPA EGVTYAPKVS
250 260 270 280 290 300
AGTSCVKWEE QTSEQVLRLH LAIGDIVPLQ TLWMENTVKL LDLVEVNNSI LADPKVMGQT
310 320 330 340 350 360
VTPGSVVYHR PSQMLLVHCK DGWIGVRSIM HKKTLTATDF YNGYLHAWYQ KNSHAYPSQC
370 380
KFQTLRLPTK TQQKTKLLLC SALSS