O77480

PR
Gene name
MTFMT (FMT)
Protein name
Methionyl-tRNA formyltransferase, mitochondrial
Names
MtFMT
Species
Bos taurus (Bovine)
KEGG Pathway
bta:286855
EC number
2.1.2.9: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O77480

Entry ID Method Resolution Chain Position Source
AF-O77480-F1 Predicted AlphaFoldDB

31 variants for O77480

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453931926 3 V>G No EVA
rs133940711 4 L>R No EVA
rs43612918 5 L>V No EVA
rs135226665 7 C>G No EVA
rs43612919 10 G>R No EVA
rs437974612 18 A>E No EVA
rs43612921 20 R>Q No EVA
rs43612922 22 S>P No EVA
rs720744773 34 A>P No EVA
rs466969149 52 W>G No EVA
rs481705092 54 V>G No EVA
rs461643500 61 Q>H No EVA
rs444736270 62 F>V No EVA
rs482610099 66 T>P No EVA
rs479682994 75 E>G No EVA
rs459566122 77 K>Q No EVA
rs442751121 87 V>G No EVA
rs480671082 91 P>H No EVA
rs443709044 98 L>M No EVA
rs471912724 108 Q>R No EVA
rs451853548 112 Y>N No EVA
rs441377116 113 E>G No EVA
rs472880124 127 V>E No EVA
rs455964166 132 R>Q No EVA
rs721759662 207 E>G No EVA
rs441707373 215 L>Q No EVA
rs476329385 216 G>S No EVA
rs456261501 216 G>V No EVA
rs797443123 218 N>H No EVA
rs1118050514 299 I>V No EVA
rs209263162 316 I>V No EVA

No associated diseases with O77480

1 regional properties for O77480

Type Name Position InterPro Accession
conserved_site Ribosomal protein S2, conserved site 8 - 19 IPR018130

Functions

Description
EC Number 2.1.2.9 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
methionyl-tRNA formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.

1 GO annotations of biological process

Name Definition
conversion of methionyl-tRNA to N-formyl-methionyl-tRNA The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96DP5 MTFMT Methionyl-tRNA formyltransferase, mitochondrial Homo sapiens (Human) PR
Q5I0C5 Mtfmt Methionyl-tRNA formyltransferase, mitochondrial Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRVLLRCCCG HLPVGGGAGR RSNPRWRALA RLSASPGWED GQGARVREKP PWRVLFFGND
70 80 90 100 110 120
QFARETLRAL HAARENKEEE LIEKLEVVTV PSPSPKGLPV KQYAVQSQLP VYEWPDVGSG
130 140 150 160 170 180
EYDVGVVASF GRLLSEAFIL KFPYGILNVH PSCLPRWRGP APIIHTILHG DTIAGVTIMQ
190 200 210 220 230 240
IKPRRFDVGP ILKQETVPVP PKSTSKELEA VLSRLGANML ISVLKNLPES LNNGRQQPAE
250 260 270 280 290 300
GVTHAPKISA ATSCIKWEEQ TSEQIFRLYR AVGNIIPLQT LWMDNTIKLL DLVEVDNSIL
310 320 330 340 350 360
SDSKLTGQAV IPGSVIYHKQ SQILLVCCKD DWIGVRSVML KKTLTATDFY NGYLHPWYQK
370 380
NSQAQPSQCR FQTLRLPPKK KQKKKIVAMQ