AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

102-180 (Predicted disordered autoinhibitory region) PR

102-180 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5HZK1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388981371	30	G>S	No	EVA
rs3388970594	42	I>F	No	EVA
rs3388983568	48	T>N	No	EVA
rs38545817	55	A>V	No	EVA
rs3388988576	65	L>H	No	EVA
rs3388981324	74	T>I	No	EVA
rs3399088262	101	F>Y	No	EVA
rs239773772	106	I>V	No	EVA
rs245585625	165	M>L	No	EVA
rs3388981347	179	Y>*	No	EVA
rs36783882	191	V>G	No	EVA
rs232747835	210	I>V	No	EVA
rs263164399	217	D>A	No	EVA
rs37074455	218	P>A	No	EVA
rs3388935246	260	L>M	No	EVA
rs33607336	312	D>E	No	EVA
rs32867624	341	S>A	No	EVA
rs3388970604	343	T>I	No	EVA
rs3388964935	346	G>A	No	EVA
rs3388985366	346	G>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Centrosomal CEP44 domain	5 - 126	IPR029157

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Midbody	Localizes to the proximal end of mother and daughter centrioles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
spindle pole	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

Name	Definition
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

Name	Definition
centriole replication	The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
centriole-centriole cohesion	The cell cycle process in which the two centrioles within a centrosome remain tightly paired.
centrosome cycle	The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DB0	CEP44	Centrosomal protein of 44 kDa	Bos taurus (Bovine)	PR
Q9C0F1	CEP44	Centrosomal protein of 44 kDa	Homo sapiens (Human)	PR
Q3B7T8	Cep44	Centrosomal protein of 44 kDa	Rattus norvegicus (Rat)	PR