Q08DB0

PR
Gene name
CEP44
Protein name
Centrosomal protein of 44 kDa
Names
Cep44
Species
Bos taurus (Bovine)
KEGG Pathway
bta:510950
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

97-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08DB0

Entry ID Method Resolution Chain Position Source
AF-Q08DB0-F1 Predicted AlphaFoldDB

No variants for Q08DB0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q08DB0

No associated diseases with Q08DB0

1 regional properties for Q08DB0

Type Name Position InterPro Accession
domain Centrosomal CEP44 domain 5 - 128 IPR029157

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Cytoplasm, cytoskeleton, spindle pole
  • Midbody
  • Localizes to the proximal end of mother and daughter centrioles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

1 GO annotations of molecular function

Name Definition
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

3 GO annotations of biological process

Name Definition
centriole replication The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
centriole-centriole cohesion The cell cycle process in which the two centrioles within a centrosome remain tightly paired.
centrosome cycle The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C0F1 CEP44 Centrosomal protein of 44 kDa Homo sapiens (Human) PR
Q5HZK1 Cep44 Centrosomal protein of 44 kDa Mus musculus (Mouse) PR
Q3B7T8 Cep44 Centrosomal protein of 44 kDa Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MATGDLKRSL RNLEQVLRSL NYPREVDCVG LVKGDTAASL PIISYSLTSY SPYVAELLVD
70 80 90 100 110 120
SNIELLAKND LRFIDTVYKL LRDQFNYKPI LTKKQFIQCG FAEWKIQIIC DILNCVMKKH
130 140 150 160 170 180
KELSSLEKTP SQQRKKTSSA KSEPCSSTEK TSTEPVGIDV TGRFVTSGKK KAVVIRHLYN
190 200 210 220 230 240
EDGANIPEDT VTDVNEAFDV CDIKAAEITI PELQVPDINC EQEDITVNPE VTALQSMLAE
250 260 270 280 290 300
CQEKLKKLTC IESRLESLEE KMKGKVLVNE KTWANLLSRV TLLETEMLLS KKNDEYMQFN
310 320 330 340 350 360
EMSEDYSSSS DMDSLNPDRK SKEERHANIP LSSGYSTVSS DSTPRTSTVN YCGLKEISEE
370 380
TTMQKMERMK KMFEETAELL KCPNH