Q5EBA1

PR
Gene name
Supv3l1
Protein name
ATP-dependent RNA helicase SUPV3L1, mitochondrial
Names
Suppressor of var1 3-like protein 1, SUV3-like protein 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:294385
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EBA1

Entry ID Method Resolution Chain Position Source
AF-Q5EBA1-F1 Predicted AlphaFoldDB

No variants for Q5EBA1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5EBA1

No associated diseases with Q5EBA1

5 regional properties for Q5EBA1

Type Name Position InterPro Accession
domain Helicase, C-terminal 353 - 521 IPR001650
domain Mitochondrial degradasome RNA helicase subunit, C-terminal domain 625 - 671 IPR022192
domain Suv3, C-terminal domain 1 558 - 598 IPR041082
domain Suv3, N-terminal 62 - 179 IPR041453
domain Suv3, DEXQ-box helicase domain 200 - 345 IPR044774

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Mitochondrion matrix
  • Mitochondrion matrix, mitochondrion nucleoid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
mitochondrial degradosome A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
3'-5' RNA helicase activity Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
double-stranded RNA binding Binding to double-stranded RNA.
protein homodimerization activity Binding to an identical protein to form a homodimer.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

12 GO annotations of biological process

Name Definition
DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
mitochondrial mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
mitochondrial mRNA surveillance The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.
mitochondrial ncRNA surveillance The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.
mitochondrial RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mitochondrial RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion.
mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth.
positive regulation of mitochondrial RNA catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VN03 Suv3 ATP-dependent RNA helicase SUV3 homolog, mitochondrial Drosophila melanogaster (Fruit fly) PR
Q8IYB8 SUPV3L1 ATP-dependent RNA helicase SUPV3L1, mitochondrial Homo sapiens (Human) PR
Q80YD1 Supv3l1 ATP-dependent RNA helicase SUPV3L1, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MSLPRCALLW ARLPAGRGAG PRAAPCSALR ALVGSFPGAS GRVPCLAASS SASGGSKAPN
70 80 90 100 110 120
TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKILDKF YKRQEIQKLS ADYGLDARLF
130 140 150 160 170 180
HQAFISFRNY IMQSHSLDVD IHIVLNDICF SAAHVDDLFP FFLRHAKQIF PVLECKDDLR
190 200 210 220 230 240
QISDLRRPPN WYPEARAIQR KIIFHSGPTN SGKTYHAIQR YLSATSGVYC GPLKLLAHEI
250 260 270 280 290 300
FEKSNAAGVP CDLVTGEERL TVEPEGKQAT HVSCTVEMCN VATPYEVAVI DEIQMIRDPA
310 320 330 340 350 360
RGWAWTRALL GLCAEEVHLC GESAAIDLVT ELLYTTGEEV EVQKYERLTP ISVLDRALES
370 380 390 400 410 420
LDNLRPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP PGTKLAQARK FNDPNDPCKI
430 440 450 460 470 480
LVATDAIGMG LNLSIRRIIF YSLIKPSINE KGEKELEPIT TSQALQIAGR AGRFSSHFKE
490 500 510 520 530 540
GEVTTMHRDD LALLKEILNR PVDPIQAAGL HPTAEQIEMF AYHLPETTLS NLIDIFVDFA
550 560 570 580 590 600
QVDGQYFVCN MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN
610 620 630 640 650 660
EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVFDLYLW LSYRFIDMFP DSSFVRSLQK
670 680 690 700 710 720
ELDVIIQEGV HNITKLIKIS ESHKLLNLEP SGSQSRLPGA SKSPARRTRG TKTGNKAAEP
730 740 750 760 770
PSPSDKELPL ASRLVQQGLL TADMLKQLQK EWLTQRPEQG KEKVGTRRKK KDPNSD