Q5EA49

PR
Gene name
MIS12
Protein name
Protein MIS12 homolog
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:767858
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EA49

Entry ID Method Resolution Chain Position Source
AF-Q5EA49-F1 Predicted AlphaFoldDB

13 variants for Q5EA49

Variant ID(s) Position Change Description Diseaes Association Provenance
rs433078221 5 P>L No EVA
rs466063591 11 Q>H No EVA
rs447579571 16 T>A No EVA
rs447579571 16 T>P No EVA
rs480641029 17 P>A No EVA
rs462124895 19 T>N No EVA
rs450234509 32 L>Q No EVA
rs483146968 35 V>A No EVA
rs458357127 37 Q>R No EVA
rs133733429 39 V>G No EVA
rs479257522 40 E>A No EVA
rs460712052 50 I>V No EVA
rs469480044 190 Q>R No EVA

No associated diseases with Q5EA49

No regional properties for Q5EA49

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5EA49

Functions

Description
EC Number
Subcellular Localization
  • Chromosome, centromere, kinetochore
  • Associated with the kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
MIS12/MIND type complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
nuclear MIS12/MIND complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
attachment of mitotic spindle microtubules to kinetochore The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
kinetochore assembly The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1T769 MIS12 Protein MIS12 homolog Gallus gallus (Chicken) PR
Q9H081 MIS12 Protein MIS12 homolog Homo sapiens (Human) PR
10 20 30 40 50 60
MSVDPMTYEA QFFGFTPQTC MLRIYIAFQD YLFEVMQAVE QVILKKLDGI PDCAISPVEI
70 80 90 100 110 120
RKCTEKFLCF MKGRFDNLFG KMEQLFLQLI LRIPPNVLLP EDKSQETQSY SEEEFHFLQK
130 140 150 160 170 180
EIEQLQEKYK TELCTKQALL AELEEQKIVQ AKLKQTLSLF DELENVGRDH GASDFREGLV
190 200
FLIQNSRKLQ NIRENVEKEG KRLKIS