Q1T769
Gene name |
MIS12 |
Protein name |
Protein MIS12 homolog |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:693254 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1T769
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1T769-F1 | Predicted | AlphaFoldDB |
No variants for Q1T769
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1T769 | |||||
No associated diseases with Q1T769
No regional properties for Q1T769
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q1T769 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| MIS12/MIND type complex | A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. |
| nuclear MIS12/MIND complex | A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| attachment of mitotic spindle microtubules to kinetochore | The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| kinetochore assembly | The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| protein localization to kinetochore | Any process in which a protein is transported to, or maintained at, the kinetochore. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVRPMAYET | QFFGFTPQTC | MLRIYLAFQD | YLFEMMVVVE | SVILKKLEAL | PAVQISRFEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKSTEKFLHF | MKARFDQLFE | KMEEVLLQLV | LSIPDNVLLP | EDRVHQQYPY | SQEEFCALQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EISQLQQQCR | AEAAAGQALR | AELEEQRAVQ | AELEKVVQWF | DGLENVCREH | GTGNFKESLV |
| 190 | 200 | ||||
| FLTQNCKKLQ | DVLRDVEEKS | KKIKKRQQLL |