Q5E9N9
Gene name |
APEX2 |
Protein name |
DNA-(apurinic or apyrimidinic site) endonuclease 2 |
Names |
APEX nuclease 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:511790 |
EC number |
3.1.11.2: Exodeoxyribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9N9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9N9-F1 | Predicted | AlphaFoldDB |
No variants for Q5E9N9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5E9N9 | |||||
No associated diseases with Q5E9N9
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.11.2 | Exodeoxyribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRLVSWNIN | GIRSPLQGVR | CEEPSSCSAM | AMGRILDKLD | ADIVCLQETK | VTRDVLTEPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIIEGYNSYF | SFSRNRSGYS | GVATFCKDSA | TPVAAEEGLS | GLLSTQNGDV | GCYGNMDDFT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEELRALDSE | GRALLTQHKI | CTWEGKEKTL | TLINVYCPHA | DPGKPERLTF | KMRFYRLLQI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RAEALLAAGS | HVIILGDLNT | AHRPIDHWDA | VNMECFEEDP | GRKWMDGLLS | NLGCESGSHM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GPFIDSYRCF | QPKQKGAFTC | WSTVSGARHL | NYGSRLDYVL | GDRTLVIDTF | QSSFLLPEVM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSDHCPVGAV | LSVSSVPAKQ | CPPLCTCFLP | EFAGTQLKIL | RFLVHFKQDP | VFKQSALQPS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NQTQVHMRKN | KARVRSTRSR | PSKTGSSRGQ | KNLMSYFQPS | SSGPQTSNLD | LPSLGTLITP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KTSEEDVMAN | VVEGQTKASE | AKDEKEIRTS | FWKSLLGGPS | PMPLCGGHRE | PCVMRTVKKP |
| 490 | 500 | 510 | |||
| GPNLGRHFYM | CARPQGPPTD | PSSRCNFFLW | SRPS |