Q568Z6
Gene name |
Ist1 |
Protein name |
IST1 homolog |
Names |
Charged multivesicular body protein 8, CHMP8 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:307833 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q568Z6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q568Z6-F1 | Predicted | AlphaFoldDB |
No variants for Q568Z6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q568Z6 | |||||
No associated diseases with Q568Z6
No regional properties for Q568Z6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q568Z6 | |||
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
| Flemming body | A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| MIT domain binding | Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein-containing complex binding | Binding to a macromolecular complex. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| abscission | The controlled shedding of a body part. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| collateral sprouting | The process in which outgrowths develop from the shafts of existing axons. |
| cytoskeleton-dependent cytokinesis | A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. |
| establishment of protein localization | The directed movement of a protein to a specific location. |
| positive regulation of collateral sprouting | Any process that activates or increases the frequency, rate or extent of collateral sprouting. |
| positive regulation of proteolysis | Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| viral capsid secondary envelopment | The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope. |
| viral release from host cell | The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLGSGFKAER | LRVNLRLVIN | RLKLLEKKKT | ELAQKARKEI | ADYLAAGKDE | RARIRVEHII |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REDYLVEAME | ILELYCDLLL | ARFGLIQSMK | ELDSGLAESV | STLIWAAPRL | QSEVAELKIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADQLCAKYSK | EYGKLCRTNQ | IGTVNDRLMH | KLSVEAPPKI | LVERYLIEIA | KNYNVPYEPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVVMAEAPVG | VETDLIDVGF | TDDVKKGGPG | RGGGGGFTAP | VGAPDGTMPM | PMPMPMPMPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSPNAPFAYP | LPKGPSDFSG | LPVGTYQAFP | NIHPPQIPAT | PPSYESVDDI | NADKNVSSAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVGPKPEAPA | KPPSRPVDNY | NTFVLPELPS | VPDTLPTASA | GASTSASEDI | DFDDLSRRFE |
| ELKKKT |