Q3V3Q7
PR
Gene name |
Pacs2 (Kiaa0602, Pacs1l) |
Protein name |
Phosphofurin acidic cluster sorting protein 2 |
Names |
PACS-2, PACS1-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217893 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3V3Q7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3V3Q7-F1 | Predicted | AlphaFoldDB |
50 variants for Q3V3Q7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389261297 | 93 | N>S | No | EVA | |
| rs46379216 | 104 | A>V | No | EVA | |
| rs3389272422 | 153 | D>N | No | EVA | |
| rs3389193911 | 176 | F>C | No | EVA | |
| rs3389237444 | 187 | V>I | No | EVA | |
| rs3389261290 | 234 | V>A | No | EVA | |
| rs3389278377 | 253 | E>D | No | EVA | |
| rs3389256804 | 262 | T>M | No | EVA | |
| rs3389248644 | 265 | V>L | No | EVA | |
| rs3389278367 | 280 | S>I | No | EVA | |
| rs262675348 | 327 | T>M | No | EVA | |
| rs3389193850 | 334 | Q>L | No | EVA | |
| rs48075263 | 340 | V>I | No | EVA | |
| rs48815710 | 348 | A>T | No | EVA | |
| rs3389223698 | 353 | E>* | No | EVA | |
| rs3389231806 | 385 | T>P | No | EVA | |
| rs3389262182 | 400 | A>T | No | EVA | |
| rs3389237372 | 420 | E>Q | No | EVA | |
| rs3389261270 | 428 | E>* | No | EVA | |
| rs3389259498 | 429 | R>L | No | EVA | |
| rs3389259504 | 434 | R>W | No | EVA | |
| rs3389261753 | 466 | N>S | No | EVA | |
| rs3389237446 | 489 | T>R | No | EVA | |
| rs3389256780 | 490 | C>Y | No | EVA | |
| rs3389248578 | 493 | A>V | No | EVA | |
| rs3389223647 | 495 | V>E | No | EVA | |
| rs3389273334 | 496 | Q>P | No | EVA | |
| rs3389261339 | 501 | T>S | No | EVA | |
| rs3389265320 | 527 | A>V | No | EVA | |
| rs3389265234 | 529 | H>Y | No | EVA | |
| rs3389261341 | 545 | K>N | No | EVA | |
| rs3389237394 | 562 | S>P | No | EVA | |
| rs3413106956 | 579 | F>I | No | EVA | |
| rs47969554 | 592 | L>Q | No | EVA | |
| rs3389237363 | 608 | I>N | No | EVA | |
| rs3389259478 | 609 | T>A | No | EVA | |
| rs3389231814 | 620 | Q>K | No | EVA | |
| rs3389262167 | 621 | L>F | No | EVA | |
| rs3389248630 | 633 | K>M | No | EVA | |
| rs3389261787 | 647 | V>I | No | EVA | |
| rs3389273409 | 655 | V>L | No | EVA | |
| rs3389237432 | 657 | P>A | No | EVA | |
| rs3389264068 | 672 | S>C | No | EVA | |
| rs3389265318 | 676 | L>F | No | EVA | |
| rs3403879426 | 688 | A>S | No | EVA | |
| rs3389259454 | 722 | V>M | No | EVA | |
| rs3389231781 | 726 | T>I | No | EVA | |
| rs3389262215 | 778 | V>I | No | EVA | |
| rs3389193831 | 848 | K>M | No | EVA | |
| rs3389256737 | 855 | F>I | No | EVA |
No associated diseases with Q3V3Q7
No regional properties for Q3V3Q7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3V3Q7 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| endoplasmic reticulum calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. |
| mitochondrion-endoplasmic reticulum membrane tethering | The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. |
| protein localization to phagophore assembly site | Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86VP3 | PACS2 | Phosphofurin acidic cluster sorting protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAERGRLGLP | GAPGALNTPV | PMNLFATWEV | DGSSPSCVPR | LCSLTLKKLA | VLRELEKELL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVVIAVKMQY | PHFLKREGNK | LQIMLQRRKR | YKNRTILGYK | TLAAGSINMA | EVMQHPSEGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVLSLCSSIK | EASVKVAEIW | IVSLSSQPID | HEDSAMQAGP | KTKSTDNYSE | EEYESFSSEQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EASDDAVQGQ | DLDEDDFDVG | KPKKQRRSIV | RTTSMTRQQN | FKQKVVALLR | RFKVSEEVLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SEQDPAEHVP | EVEEDLDLLY | DTLDVENPSD | SGPDMDDDDS | VLSTPKPKLR | PYFEGLSHSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SQTEIGSIHS | ARSHREPPSP | ADVPEKTRSL | GGKQQLSDSV | SDTVALSAAV | PREPSGQPED |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPEAETSTLD | VFTEKLPPSG | RIIKTESLVI | PSTRSESKPA | GRRGRSTSLK | ERQPARPQNE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RANSLDNERC | PDTRSQLQIP | RKTVYDQLNH | ILISDDQLPE | NIILVNTSDW | QGQFLSDVLQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KHTLPVVCTC | SAADVQAAFS | TIVSRIQRYC | NCNSQPPTPV | KIAVAGAQHY | LSAILRLFVE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QLSHKTPDWL | GYMRFLIIPL | GSHPVARYLG | SVDYRYNNFF | QDLAWRDLFN | KLEAQSSVQD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TPDIVSRITQ | YISGANCAHQ | LPIAEAMLTY | KQKSPDEESS | QRFIPFVGVV | KVGIVEPSSA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TSGDSDDAAP | SSSSILSSTP | PSASTSPAAK | EASPTPPSSP | SVSGGLSSPS | QGVGAELMGL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QVDYWTAAQP | ADRKRDAEKK | DMPTTKNTLK | CTFRSLQVSR | LPSSGEAAAT | PTMSMTVVTK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EKNKKVMFLP | KKTKDKEVES | KSQCIEGISR | LICTAKHQQN | MLRVLIDGVE | CSDVKFFQLA |
| 850 | 860 | ||||
| AQWSSHVKHF | PICIFGHSKA | TF |