Q3V384
Gene name |
Afg1l |
Protein name |
AFG1-like ATPase |
Names |
Lactation elevated protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:215951 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3V384
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3V384-F1 | Predicted | AlphaFoldDB |
26 variants for Q3V384
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389099810 | 18 | R>L | No | EVA | |
| rs3389065276 | 31 | V>L | No | EVA | |
| rs36732070 | 65 | R>H | No | EVA | |
| rs3389107281 | 67 | K>N | No | EVA | |
| rs3401085945 | 69 | L>* | No | EVA | |
| rs3401375695 | 69 | L>M | No | EVA | |
| rs3389098165 | 84 | K>R | No | EVA | |
| rs3389107341 | 89 | R>S | No | EVA | |
| rs3389089568 | 94 | Q>H | No | EVA | |
| rs3389089548 | 122 | L>P | No | EVA | |
| rs3389075742 | 157 | R>* | No | EVA | |
| rs3389097543 | 158 | K>R | No | EVA | |
| rs3389103182 | 169 | D>E | No | EVA | |
| rs3389070500 | 177 | L>I | No | EVA | |
| rs37022437 | 240 | V>I | No | EVA | |
| rs3389099811 | 243 | T>P | No | EVA | |
| rs3401149296 | 273 | D>A | No | EVA | |
| rs36578885 | 273 | D>N | No | EVA | |
| rs3389075719 | 375 | N>I | No | EVA | |
| rs3389085869 | 397 | F>L | No | EVA | |
| rs3389103197 | 404 | I>F | No | EVA | |
| rs3389096289 | 442 | A>D | No | EVA | |
| rs3389085886 | 444 | L>I | No | EVA | |
| rs3389107349 | 451 | E>K | No | EVA | |
| rs864286084 | 475 | G>W | No | EVA | |
| rs3389085902 | 476 | D>N | No | EVA |
No associated diseases with Q3V384
No regional properties for Q3V384
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3V384 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial electron transport, cytochrome c to oxygen | The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. |
| mitochondrial protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32PX9 | Afg1l | AFG1-like ATPase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASWSPLVT | LRSAARSRLT | GRGVGCGARV | VAIPPPAPGP | GKPLWKAYTV | QTSEGVRPTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASEARLKALA | VCHGPLDHYD | FLIKSQELRE | DEHQRRVVQC | LQKLQEDLKG | YSIEEGGLFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLFSRNKPPK | GLYVYGDVGT | GKTMVMDMFY | AYVETKRKKR | VHFHGFMLDV | HRRIHHLKQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPKRKAGFMA | KSYDPIAPIA | EEISQETSLL | CFDEFQVTDI | ADAMILKQLF | ENLFKNGVVV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VATSNRPPED | LYKNGLQRAN | FVPFIAVLKE | YCDTLQLDSG | VDYRKRELAP | AGKLYYLTSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADVEAVVDKL | FDELAQKQND | LTSPRILKVQ | GRELRLNKAC | GSVADCTFEE | LCERPLGASD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YLELSKNFDT | VIIRNIPQFS | LAKRTQARRF | ITLIDNFYDF | KVRIICSASA | PISSLFLHQH |
| 430 | 440 | 450 | 460 | 470 | |
| QDSESDQSRI | LMDDLGLSQD | SAGLSMFTGE | EEIFAFQRTI | SRLTEMQTEQ | YWIEGDRSRK |