Q3UJV1
Gene name |
Ccdc61 |
Protein name |
Centrosomal protein CCDC61 |
Names |
Coiled-coil domain-containing protein 61, VFL3 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:232933 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3UJV1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UJV1-F1 | Predicted | AlphaFoldDB |
18 variants for Q3UJV1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs222379252 | 5 | A>P | No | EVA | |
| rs3388872183 | 20 | V>M | No | EVA | |
| rs3412161871 | 53 | D>V | No | EVA | |
| rs3388883415 | 78 | S>N | No | EVA | |
| rs3388883411 | 108 | A>S | No | EVA | |
| rs1134445568 | 113 | Q>E | No | EVA | |
| rs3690595 | 187 | T>A | No | EVA | |
| rs3388863709 | 252 | E>* | No | EVA | |
| rs3397624514 | 297 | S>A | No | EVA | |
| rs3388863654 | 316 | S>C | No | EVA | |
| rs3388883901 | 325 | R>Q | No | EVA | |
| rs3388857413 | 362 | Q>H | No | EVA | |
| rs32433661 | 394 | G>C | No | EVA | |
| rs3388875509 | 395 | R>L | No | EVA | |
| rs36737884 | 455 | T>M | No | EVA | |
| rs32198643 | 470 | A>T | No | EVA | |
| rs3388880164 | 475 | W>G | No | EVA | |
| rs3388867798 | 482 | S>G | No | EVA |
No associated diseases with Q3UJV1
No regional properties for Q3UJV1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3UJV1 | |||
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| centriolar subdistal appendage | A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell projection organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. |
| centriole assembly | A cellular process that results in the assembly of one or more centrioles. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JPP8 | Ccdc61 | Centrosomal protein CCDC61 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQPAGLQVD | YIFRGVEHAV | RVVVSGQVLE | LEVEDRMTAD | QWRGEFDANF | IEDLTHKTGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKQFSIFCNM | LESALTQSSE | SVTLDLLTYT | DLESLRSRKL | GGRPGALAPR | SAQLNSKRYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILIYSVEFDR | IHYPLPLPYQ | GKPDPVVLQG | IIRSLKEELG | HLRGLNGGQD | ARETEIWHLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EQVTRLTSEK | RELEAQLGRS | REEALAGRAA | RQEAESLRGL | VRGLELELRQ | ERGLGGRAAG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RRSQDSRRLA | KELEEVKASE | RNLRARLKTL | NSELAMYRRG | RRTLPPVAVR | EGRASSSRER |
| 310 | 320 | 330 | 340 | 350 | 360 |
| STSRGRAVTR | SSSRESSRGA | RGRGRPAHPS | PSPTGSRAPR | FDPTAFVKAK | EKKQREIRMK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QQQQQRNRMG | SGGSGDGPSV | SWSQQTRPAA | AVTGRGDAVN | RSRNRSSSVD | SFRSRCSSVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SCSELEDFSH | SVSRSRRCRG | RGKPPSPTPW | SRSKTKSTTQ | ERSDHQRHLA | SSGGWVPIKE |
| 490 | 500 | 510 | |||
| YSSDFQGADM | AEIDARLKAL | QEYMNRLDTR | S |