A0JPP8

PR
Gene name
Ccdc61
Protein name
Centrosomal protein CCDC61
Names
Coiled-coil domain-containing protein 61, VFL3 homolog
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:292680
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

259-353 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JPP8

Entry ID Method Resolution Chain Position Source
AF-A0JPP8-F1 Predicted AlphaFoldDB

1 variants for A0JPP8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3318945146 197 G>D No EVA

No associated diseases with A0JPP8

No regional properties for A0JPP8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A0JPP8

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
  • Cytoplasm, cytoskeleton, cilium basal body
  • Localization at the centriolar satellite is dependent on intact microtubule network
  • Localizes at the centriole subdistal appendages and proximal ends
  • Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
centriolar satellite A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
centriolar subdistal appendage A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

3 GO annotations of biological process

Name Definition
cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
centriole assembly A cellular process that results in the assembly of one or more centrioles.
mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3UJV1 Ccdc61 Centrosomal protein CCDC61 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEQPAGLQVD YMFRGVEHAV RVVVSGQVLE LEVEDRMTAD QWRGEFDANF IEDLTHKTGN
70 80 90 100 110 120
FKQFSIFCNM LESALTQSSE SVTLDLLTYT DLESLRSRKL GGRPGPCPRS AQLNSKRYLI
130 140 150 160 170 180
LIYSVEFDRI HYPLPLPYQG KPDPVVLQGI IRSLKEELGH LRGMNGGQDA RETEIWHLRE
190 200 210 220 230 240
QVTRLASEKR ELEAQLGRSR EEALAGRAAR QEAESLRGLV RGLELELRQE RGLGGRAAGR
250 260 270 280 290 300
RSQDCRRLAK ELEEVKASER NLRARLKTLN CELAMYRRGR RTLPAGARED RALSSRERST
310 320 330 340 350 360
SRGRTATRSS SRESNRGARS HGRPAHPSPS PTGSRVPRFD PTAFVKAKEK KQREIRMKRQ
370 380 390 400 410 420
QQQQQQRNRM GSGGSGDGPS VSWSHQTRPP AAVTGRGDAA NRSRNRSSSV DSFRSRCSSV
430 440 450 460 470 480
SSCSELEDFS QSVSKSRRCR GRGKPPSPIP WSGSKTKSTT RERNNHQRHL ASSGAWVPIK
490 500 510
EYSSDYQGAD MAEIDARLKA LQEYMNRLDT RS